Download OU M.Pharma Pharmacology 1st Sem 2020 6118PCI Pharmacological And Toxicological Screening Methods I Question Paper

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Code No. 6118/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmacology) I-Semester (PCI) (Main & Backlog) Examination, January 2020

Subject: Pharmacological and Toxicological Screening Methods - I

Time: 3 Hrs Max. Marks: 75

Note: Answer Any Five Questions. All Questions Carry Equal Marks.

1. (a) Describe in detail about regulations for laboratory animal care as per CPCSEA Guidelines. (10)
   

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   (b) Enlist the applications of transgenic animals in preclinical research. (5)
2. Define memory. List the animal models for evaluating the test drug for improving memory and describe any three models. (15)
3. Describe the preclinical screening procedures for the following:
   (a) Antifertility agents (8)
   (b) Analgesics (7)

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4. Define diabetes. List the methods available to induce diabetes and describe three models in the screening of anti-diabetic agents. (15)
5. Explain the in vitro and in vivo screening methods for immunomodulators. (15)
6. Write short notes on:
   (a) Alternate animal experiments (7)
   (b) Immunoassay for digoxin (8)

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7. Describe the screening methods for the evaluation of the following activities of a compound:
   (a) Hepatoprotective drugs (8)
   (b) Anti ulcer agents (7)
8. Describe the screening methods used to evaluate the therapeutic activity of the following:
   (a) Anti-asthmatics (8)
   

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   (b) Diuretics (7)

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