OU M.Pharm Question Papers Last 10 Years 2010-2020 || Osmania University
FACULTY OF PHARMACY
M. Pharmacy (Pharm. Analysis) II-Semester (PCI) (Main) Examination, August 2019
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Subject : Advanced Instrumental Analysis
Time: 3 Hrs Max. Marks: 75
Note: Answer any Five Questions. All Questions Carry Equal Marks.
- (a) Explain the following chromatographic parameter (i) Capacity factor (ii) Selectivity (iii) Resolution 9
(b) Explain the principle involved in UPLC and compare it with HPLC in terms of different parameters? 7 - (a) Explain the Principle involved in size exclusion chromatography and write abt commercially available columns and their properties. 7
(b) Explain in detail abt derivatisation in Gas chromatography 8 - (a) Explain the principle and applications of super critical fluid chromatography? 7
(b) What is capillary electrophoreses? Explain its principle, methods and modes of CE? 8 - (a) What is the theory involved in mass spectrometry and explain the following ionization techniques (i) Electron impact (ii) field ionization (iii) MALDI ionization 10
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(b) Explain Mc. Lafferty arrangement with example. 5 - (a) Define chemical shift? Explain the factors influencing chemical shift. 7
(b) Draw a schematic NMR spectra and explain the interpretation for the following compnds (i) Diethylether (ii) Ethoxyaceticacid (ii)n - propyl formate - (a) Explain the following techniques
1. NOESY 2. COSY 8--- Content provided by FirstRanker.com ---
(b) Explain the following mass analyzers in detail
1. Quadruple 2. Time of flight - (a) What is enantiomeric separations? Explain role of HPLC in chiral analysis? 7
(b) Write the principle, head space sampling and columns used in gas chromatography - (a) Explain the principle involved in the following hyphenated techniques
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(i) LC-MS (ii) LC-NMR (iii) CE-MS 7
(b) Write the applications of
(i) LC-MS (i) LC-NMR (Ill) CE-MS 8
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