FACULTY OF PHARMACY
M. Pharmacy (Pharm. Chemistry) II-Semester (PCI) (Main) Examination, August 2018
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Subject : Advanced Organic Chemistry-II
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
- a) Discuss the basic Principles of green chemistry
b) Discuss the merits, demerits and any five applications of micro wave assisted reactions. (8+7) - What are pericyclic reactions? Discuss Cycloaddition and electrocyclic reactions in presence of heat and photo light with mechanism and stereochemistry.
- a) What is homogenous and heterogenous catalysis? Explain advantages and disadvantages. Discuss examples of drug syntheses involving Wilkinson catalyst and Ziegler — Natta catalyst (one each)
b) Discuss the theory and applications of phase transfer catalysts (8+7) - Discuss different methods of asymmetric synthesis with suitable examples
- Explain the basic principles of solid phase peptide synthesis. Write about solid supports, linkers, protecting and de protecting groups used in solid phase peptide synthesis
- a) Discuss any five synthetic applications of Ultra sound assisted reactions
b) Discuss sequential strategies in solution phase peptide synthesis with two case studies (5+10) - a) Explain Cahn, Ingold, Prelog (CIP) sequence rules with suitable examples
b) Discuss cis-trans isomerism in cyclic and double bond containing compounds (7+8) - Write a note on: (5+5+5)
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a) Photo-oxidation reactions
b) Sigmatropic reactions
c) Bio catalysts
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