Download OU (Osmania University) M.Pharma-Ph.Chemistry (Master of Pharmacy) 2nd Semester 2018 1223 Computer Aided Drug Design Previous Question Paper
- -
CODE NO: 1223/PCI
FACULTY OF PHARMACY
M.Pharmacy (Pharmaceutical Chemistry) II-Semester (PCI) (Main)
Examination, August 2018
Subject: Computer Aided Drug Design
Time: 3 Hrs Max. Marks: 75
Note: Answer any Five questions. All questions carry equal marks
1. a) Discuss abt Substituent Hydrophobicity constant, Hammet constant and Taft
steric constant
b) Give a hypothetical Hansch equation for compnds with higher log p Values and
explain each term (8+7)
2. a) Enumerate the steps involved in 3D QSAR studies to predict the biological
activity
b) Write the advantages of Free Wilson analysis (8+7)
3. a) Write a note on molecular mechanics
b) Discuss abt the importance of energy minimization in molecul ar modeling (8+7)
4. a) Explain abt varis docking methods and write their advantages
b) Discuss abt Knowledge based and Consensus scoring techniques in docking (8+7)
5. a) What is homology modeling and enumerate steps involved in homology modeling (9+6)
b) Write a short note on de novo drug design
6. Write a short note on
a) Drug likeness screening
b) Pharmacophore based virtual screening (8+7)
7. a) Explain the techniques to predict the active site of a receptor in denovo drug
design
b) Explain, how new DHFR inhibitors are designed using molecular docking? (8+7)
8. Write a short note on
a) Requirements to perform QSAR studies with suitable example
b) Statistical methods used in QSAR (8+7)
*******
FirstRanker.com - FirstRanker's Choice
- -
CODE NO: 1223/PCI
FACULTY OF PHARMACY
M.Pharmacy (Pharmaceutical Chemistry) II-Semester (PCI) (Main)
Examination, August 2018
Subject: Computer Aided Drug Design
Time: 3 Hrs Max. Marks: 75
Note: Answer any Five questions. All questions carry equal marks
1. a) Discuss abt Substituent Hydrophobicity constant, Hammet constant and Taft
steric constant
b) Give a hypothetical Hansch equation for compnds with higher log p Values and
explain each term (8+7)
2. a) Enumerate the steps involved in 3D QSAR studies to predict the biological
activity
b) Write the advantages of Free Wilson analysis (8+7)
3. a) Write a note on molecular mechanics
b) Discuss abt the importance of energy minimization in molecul ar modeling (8+7)
4. a) Explain abt varis docking methods and write their advantages
b) Discuss abt Knowledge based and Consensus scoring techniques in docking (8+7)
5. a) What is homology modeling and enumerate steps involved in homology modeling (9+6)
b) Write a short note on de novo drug design
6. Write a short note on
a) Drug likeness screening
b) Pharmacophore based virtual screening (8+7)
7. a) Explain the techniques to predict the active site of a receptor in denovo drug
design
b) Explain, how new DHFR inhibitors are designed using molecular docking? (8+7)
8. Write a short note on
a) Requirements to perform QSAR studies with suitable example
b) Statistical methods used in QSAR (8+7)
*******
- -
Code No. 1221/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharm. Chemistry) II-Semester (PCI) (Main) Examination,
August 2018
Subject : Advanced Spectral Analysis
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 a) Discuss any two 2DNMR (NOESY, COSY, HETCOR) techniques of and explain
their importance in structural interpretation of organic compnds.
2 a) Write the wood ward ? Fieser rules for ? ? , -Carbonyl Compnds and 1, 3 ?
butadiene?s. Calculate ? max for the following compnds.
b) Explain the importance of meta stable ion peaks and isotopic peaks in mass
spectroscopy. (9+6)
3 Discuss the principle, instrumentation and applications of any two of the following
a) LC-MS b) HPTLC c) Super Critical fluid Chromotography.
4 Explain principle instrumentation and applications of any two of the following
techniques
a) DSC b) TGA c) Raman Spectroscopy (3x5)
5 a) Discuss the fragmentation of important functional grps in mass spectroscopy.
b) Explain MC Lafferty rearrangement and ring rule (10+5)
6 a) Explain the principle and applications of any two of the following instrumentation
techniques:
a) Flash chromcotography
b) LC-FTIR
c) Ion exclusion chromatography
7 Write a note on any two of the following
a) ELISA and its applications
b) Radioiumuno assay of insulin
c) Bioassays
..2
FirstRanker.com - FirstRanker's Choice
- -
CODE NO: 1223/PCI
FACULTY OF PHARMACY
M.Pharmacy (Pharmaceutical Chemistry) II-Semester (PCI) (Main)
Examination, August 2018
Subject: Computer Aided Drug Design
Time: 3 Hrs Max. Marks: 75
Note: Answer any Five questions. All questions carry equal marks
1. a) Discuss abt Substituent Hydrophobicity constant, Hammet constant and Taft
steric constant
b) Give a hypothetical Hansch equation for compnds with higher log p Values and
explain each term (8+7)
2. a) Enumerate the steps involved in 3D QSAR studies to predict the biological
activity
b) Write the advantages of Free Wilson analysis (8+7)
3. a) Write a note on molecular mechanics
b) Discuss abt the importance of energy minimization in molecul ar modeling (8+7)
4. a) Explain abt varis docking methods and write their advantages
b) Discuss abt Knowledge based and Consensus scoring techniques in docking (8+7)
5. a) What is homology modeling and enumerate steps involved in homology modeling (9+6)
b) Write a short note on de novo drug design
6. Write a short note on
a) Drug likeness screening
b) Pharmacophore based virtual screening (8+7)
7. a) Explain the techniques to predict the active site of a receptor in denovo drug
design
b) Explain, how new DHFR inhibitors are designed using molecular docking? (8+7)
8. Write a short note on
a) Requirements to perform QSAR studies with suitable example
b) Statistical methods used in QSAR (8+7)
*******
- -
Code No. 1221/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharm. Chemistry) II-Semester (PCI) (Main) Examination,
August 2018
Subject : Advanced Spectral Analysis
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 a) Discuss any two 2DNMR (NOESY, COSY, HETCOR) techniques of and explain
their importance in structural interpretation of organic compnds.
2 a) Write the wood ward ? Fieser rules for ? ? , -Carbonyl Compnds and 1, 3 ?
butadiene?s. Calculate ? max for the following compnds.
b) Explain the importance of meta stable ion peaks and isotopic peaks in mass
spectroscopy. (9+6)
3 Discuss the principle, instrumentation and applications of any two of the following
a) LC-MS b) HPTLC c) Super Critical fluid Chromotography.
4 Explain principle instrumentation and applications of any two of the following
techniques
a) DSC b) TGA c) Raman Spectroscopy (3x5)
5 a) Discuss the fragmentation of important functional grps in mass spectroscopy.
b) Explain MC Lafferty rearrangement and ring rule (10+5)
6 a) Explain the principle and applications of any two of the following instrumentation
techniques:
a) Flash chromcotography
b) LC-FTIR
c) Ion exclusion chromatography
7 Write a note on any two of the following
a) ELISA and its applications
b) Radioiumuno assay of insulin
c) Bioassays
..2
- -
Code No. 1221/PCI
-2-
8. a) Draw a rgh ?HNMR Spectra for the following compnds with proton splitting
b) How do y interp ret the following functional grps in IR? (any six)
i) NO
2
ii) SO
2
iii) NH
2
iV) R -
O
II
C - OR V) CONH
Vi) COOH Vii) CN Viii) CHO ix) -
O
II
C - V) OH (9+6)
*******
Code No. 1221/PCI
-2-
8. a) Draw a rgh ?HNMR Spectra for the following compnds with proton splitting
b) How do y interp ret the following functional grps in IR? (any six)
i) NO
2
ii) SO
2
iii) NH
2
iV) R -
O
II
C - OR V) CONH
Vi) COOH Vii) CN Viii) CHO ix) -
O
II
C - V) OH (9+6)
*******
Code No. 1221/PCI
-2-
8. a) Draw a rgh ?HNMR Spectra for the following compnds with proton splitting
b) How do y interp ret the following functional grps in IR? (any six)
i) NO
2
ii) SO
2
iii) NH
2
iV) R -
O
II
C - OR V) CONH
Vi) COOH Vii) CN Viii) CHO ix) -
O
II
C - V) OH (9+6)
*******
FirstRanker.com - FirstRanker's Choice
This post was last modified on 19 July 2020