Download OU M.Pharma Ph.Chemistry 2nd Sem 2019 13324PCI Advanced Organic Chemistry Ii Question Paper

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Code No. 13324/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutical Chemistry) II-Semester (PCI) (Main) Examination, August 2019

Subject: Advanced Organic Chemistry - II

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. (a) Explain the principle involved in the continuous flow reactors. Discuss their industrial Applications.
   

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   (b) Write a note on solvents used in microwave assisted synthesis. (8+7)
2. (a) Discuss the sequential strategies for solution phase peptide synthesis.
   (b) Write a note on side reactions in peptide synthesis. (8+7)
3. (a) What are pericyclic reactions? Discuss any two types of pericyclic reactions with mechanism.
   (b) Discuss the basic principles of photo chemical reactions. (10+5)

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4. (a) What is heterogeneous catalysis ? Write the advantages and disadvantages
   (b) Discuss in detail about the homogeneous catalysis used in drug synthesis with example. (8+7)
5. (a) Write a note on chiral auxiliaries and catalytic asymmetric synthesis. (9+6)
   (b) What are racemates? Explain resolution of racemates and its applications.
6. Write a short note on : (3+6+6)
   

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   (a) Specific rotation
   (b) Protecting agents in peptide synthesis
   (c) Ultra sound assisted synthesis
7. (a) Discuss about protection, solid supports, linkers activation procedures in solid phase peptide synthesis.
   (b) HF cleavage protocols. (10+5)

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8. Write a short note on:
   (a) Applications of Microwave technology in organic reactions.
   (b) Phase transfer catalysis (8+7)

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