Download OU M.Pharma Ph.Chemistry 2nd Sem 2019 13325PCI Computer Aided Drug Design Question Paper

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Code No. 13325/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutical Chemistry) II-Semester (PCI) (Main) Examination, August 2019

Subject: Computer Aided Drug Design

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. (a) Discuss in detail about various parameters used in QSAR.
   

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   (b) How is substituent hydrophobicity constant used in QSAR? Discuss with an example equation. (10+5)
2. (a) What is Hansch analysis and discuss how it is used in predicting the biological activity?
   (b) Give the advantages and disadvantages of Hansch analysis. (9+6)
3. (a) What is quantum mechanics? Describe the use of quantum mechanics in drug design.
   (b) What is molecular docking? Discuss the steps involved in molecular docking? (8+7)

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4. (a) What is Homology modeling? Discuss its importance in drug design. (8+7)
   (b) Write a note on fragment based drug design.
5. (a) What is known as pharmacophore? Discuss the concept of Pharmacophore based virtual screening.
   (b) Write a note on pharmacophore modeling. (8+7)
6. (a) Write a note on Scoring techniques in Molecular docking.
   

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   (b) Discuss various models for predicting ADMET properties. (7+8)
7. (a) What is virtual screening? Discuss about druglikeness screening.
   (b) Write a note on Privileged structures. (8+7)
8. (a) What is bioactive conformation? Discuss various energy minimization techniques. (8+7)
   (b) Write a note on application of Free Wilson analysis in drug design.

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