OU M.Pharm Question Papers Last 10 Years 2010-2020 || Osmania University
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) II-Semester (PCI) (Main) Examination, August 2018
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Subject: Advance Biopharmaceutics & Pharmacokinetics
Time: 3 Hrs Max. Marks : 75
Note: Answer any five questions. All questions carry equal marks.
- (a) Derive expressions for Cmax and tmax for one compartment open model, extra vascular administration. (8)
(b) Explain with examples cytochrome p450 based drug interactions. (7) - (a) What are the different methods for assessment of bioavailability? (8)
(b) What are the special concerns in bioavailability and bioequivalence studies. (7) - (a) Write the significance of different volumes of distribution in two compartment model. (5)
(b) Write a note on volume of distribution and clearance. (10) - (a) Explain various methods to study drug permeability. (7)
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(b) Write about IVIVC. (8) - (a) Derive Michaelis-Menten equation. How do you estimate Km and Vmax. (10)
(b) How do you compare dissolution profiles? (5) - (a) Explain the applications of pharmacokinetic principles in controlled release dosage forms. (8)
(b) Write a note on micro climate intracellular pH and tight junction complex. (7) - (a) Enumerate physicochemical factors of the drug affecting dissolution. (7)
(b) Explain the kinetics of IV infusion for one compartment model. (8) - (a) Explain various cross over designs in bioequivalence studies. (7)
(b) Write in detail about compartment models. (8)
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