Download OU M.Pharma Pharmaceutics 2nd Sem 2018 1210PCI Advance Biopharmace. And Pharmacokinetics Question Paper

Download OU (Osmania University) M.Pharma-Pharmaceutics (Master of Pharmacy) 2nd Semester 2018 1210PCI Advance Biopharmace. And Pharmacokinetics Previous Question Paper

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Code No. 1210/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) II-Semester (PCI) (Main) Examination, August 2018
Subject: Advance Biopharmace. & Pharmacokinetics
Time: 3 Hrs Max. Marks : 75
Note: Answer any five questions. All questions carry equal marks.
1 (a) Derive expressions for c
max
and t
max
for one compartment open model, extra
vascular administration. (8)
(b) Explain with examples cytochrome p450 based drug interactions. (7)
2 (a) What are the different methods for assessment of bioavailability? (8)
(b) What are the special concerns in bioavailability and bioequivalence
studies. (7)
3 (a) Write the significance of different volumes of distribution in two compatment
model. (5)
(b) Write a note on volume of distribution and clearance. (10)
4 (a) Explain varis methods to study drug permeability. (7)
(b) Write abt IVIVC. (8)
5 (a) Derive Michaelis-Menten equation. How do y estimate K
m
and V
m
. (10)
(b) How do y compare dissolution profiles? (5)
6 (a) Explain the applications of pharmacokinestic principles in controlled release
dosage forms. (8)
(b) Write a note on micro climate intracellular pH and tight junction complex. (7)
7 (a) Enumerate physicochemical factors of the drug affecting dissolution. (7)
(b) Explain the kinetics of IV infusion for one compartment model. (8)
8 (a) Explain varis cross over designs in bioequivalence studies. (7)
(b) Write in detail abt compartment models. (8)
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