Download OU M.Pharma Pharmaceutics 2nd Sem 2019 13163PCI Molecular Pharmaceutics Nano Technology And Targeted Drug Delivery Systems Question Paper

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Code No. 13163/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmaceutics) II-Semester (PCI) (Suppl.) Examination, February 2019

Subject: Molecular Pharmaceutics

(Nano Technology and Targeted Drug Delivery Systems)

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

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1. a. What are the ideal properties of a carrier? (5)
   b. Explain different types of drug targeting with examples? (10)
2. a. What are the limitations of drug targeting to tumor? Explain EPR targeting? (7)
   b. What are the active targeting methods to target tumor? (8)
3. a. Explain blood brain barrier? What the factors affecting drug transport across the BBB? (6)
   

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   b. Explain various non -invasive targeting methods to brain? (9)
4. a. Describe in detail various methods of preparation of microspheres? (10)
   b. Explain the drug release mechanism from microspheres? (5)
5. a. Explain in detail nasal drug delivery system? (10)
   b. Write a note on preparation of Monoclonal antibodies? (5)

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6. a. What are aerosols? Explain various propellants used in the manufacturing of Aerosols. (7)
   b. Explain different methods to characterize aerosols? (8)
7. a. Define gene therapy? Explain few diseases targeted for treatment using gene drug delivery system. (9)
   b. Explain aptamers role in targeted cancer therapy? (6)
8. Write a note on following
   

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   a. Stealth liposomes
   b. Phytosomes
   c. Aquasomes (15)

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