Download OU M.Pharma Pharmaceutics 2nd Sem 2019 13164PCI Advance Biopharmaceutics And Pharmacokinetics Question Paper

Download OU (Osmania University) M.Pharma-Pharmaceutics (Master of Pharmacy) 2nd Semester 2019 13164PCI Advance Biopharmaceutics And Pharmacokinetics Previous Question Paper

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Code No. 13164/PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) II-Semester (PCI) (Suppl.) Examination, February 2019
Subject: Advance Biopharmaceutics & Pharmacokinetics
Time: 3 Hrs Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1. (a) Write in detail abt mechanism of drug absorption with suitable diagrams .(10)
(b) State and Explain the Noyes-Whitney equation. (5)
2. Write notes on
(a) pH-Partition hypothesis and its limitations (8)
(b) Explain the pharmacokinetic and pharmacodynamic drug-drug interaction. (7)
3. (a) Discuss abt the theories proposed for the dissolution proce ss and the factors
affecting dissolution. (10)
(b) What is in-vitro-in-vivo correlations (IVIVC) and explain in brief. (5)
4. (a) How do y calculate absorption rate constant from plasma -concentration data
following an oral dose using Wagner Nelson method. (8)
(b) Explain the varis methods for assessment of bioavailability . (7)
5. (a) Define Non-Linear pharmacokinetics. How do y estimate the pharmacokinetic
parameters (K
max
and V
max
) by using Michaelis-Menten equation. (10)
(b) Explain the biopharmaceutical classification systems (BCS) with examples and
what are its application (5)
6. (a) Describe the experimental protocol and analysis of data for bioequivalence studies
for conventional dosage form. (10)
(b) Write the application of pharmacokinetics in targeted drug delivery system. (5)
7. (a) Explain the varis methods for determining absorption of drugs in-vitro,in-situ
and in- vivo and their correlation with examples. (10)
(b) Pharmacokinetics of 500 mg paracetamol after oral administration is best
described by the equation C=1.18(e
-0. 24t
_
e
-1.6t
).Calculate the C
max
, t
max
and t
1/2
of the drug. (5)
8. A dose of ciprofloxacin 250 mg I.V.bolus was administered to a patient and the plasma
concentration vs time data is obtained. Assume the drug follows two compartment
open model. Calculate all possible pharmacokinetic parameters. (15)
Time(hrs) 0.25 0.5 0.75 1.5 2 2.5 3 5 6 7
Plasma conc. (?g/ml) 5.38 4.33 3.5 2.99 2.12 1.70 1.43 1.05 0.80 0.70
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