Download OU M.Pharma Pharmacology 2nd Sem 2019 13328 PCI Pharmacological And Toxicological Screening Methods ? Ii Question Paper

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FACULTY OF PHARMACY

Code No. 13328/ PCI

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M. Pharmacy (Pharmacology) II - Semester (PCI) (Main) Examination, August 2019

Subject: Pharmacological & Toxicological Screening Methods - II

Time: 3 Hrs

Max.Marks: 75

Note: Answer any five questions. All questions carry equal marks.

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1. Discuss in detail the determination of LD50 in acute toxicity testing of drugs as per OECD. What is its significance? (15)
2. Write short notes on:
   1. Acute eye irritation testing.
   2. Dermal toxicity studies. (15)
3. What is carcinogenesis? How do you test the compounds for carcinogenicity? Give details. (15)

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4. Define IND. Discuss the studies needed for IND submission. (15)
5. Define safety pharmacology? Explain the scope, importance and principles of safety pharmacology. (15)
6. Write short notes on:
   1. Alternatives to animal toxicity testing
   2. Applications of toxicokinetic studies. (15)

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7. Explain the importance of OECD principles of good Laboratory Practice (GLP) in drug development. (15)
8. Write notes on:
   1. Ames test for genotoxicity
   2. Teratogenicity studies. (15)

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