Download OU M.Pharma Pharmacology 2nd Sem 2019 13329 PCI Principles Of Drug Discovery Question Paper

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Code No. 13329/ PCI

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FACULTY OF PHARMACY

M. Pharmacy (Pharmacology) II - Semester (PCI) (Main) Examination, August 2019

Subject: Principles of Drug Discovery

Time: 3 Hrs Max.Marks: 75

Note: Answer any five questions. All questions carry equal marks.

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1. a) Write a note on target identification and validation.
   b) Describe about role of transgenic animals in target validation.
2. a) Write a note on solid phase synthesis.
   b) Explain in brief about cell based high throughput screening.
3. a) Write a note on traditional drug design.
   

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   b) Explain in detail about virtual screening techniques.
4. a) Write a note on docking based screening.
   b) Describe in brief about Hansch analysis and Free Wilson analysis.
5. a) Write the advantages of prodrug design.
   b) Describe the practical consideration of prodrug design.

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6. a) Explain in brief about role of protein micro array in drug discovery.
   b) Describe in detail about types of protein structure.
7. a) Write a note on types of fluorescence screens in HTS.
   b) Describe the concept of rational drug design.
8. a) Write a note on de-novo drug design.
   

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   b) Describe in brief about 3D -QSAR.