Download OU M.Pharma Pharmacology 2nd Sem 2020 6123 PCI Principles Of Drug Discovery Question Paper

Download OU (Osmania University) M.Pharma-Pharmacology (Master of Pharmacy) 2nd Semester 2020 6123 PCI Principles Of Drug Discovery Previous Question Paper

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Code No. 6123 / PCI
FACULTY OF PHARMACY
M. Pharmacy (Pharmacology) II ? Semester (PCI) (Suppl.) Examination,
January 2020
Subject: Principles of Drug Discovery
Time: 3 Hours Max.Marks: 75

Note: Answer any five questions. All questions carry equal marks.
1 a) Discuss the role of transgenic animals in drug discovery. 10
b) Explain in brief the role of genomics in target identification. 5

2 a) Describe the methods of lead optimization. 8
b) Write a note on protein structure prediction and molecular modelling. 7

3 a) Write a note on 3D QSAR. 7
b) Explain in brief abt electronic parameters used in QSAR. 8

4 a) Explain abt the identification of pharmacophore in computer aided drug design. 8
b) Write a note on CoMSIA. 7

5 a) What do y understand abt De Novo drug design? 7
b) Explain the role of physicochemical properties in relation to biological activity and
drug design. 8

6 a) Write a note on design of pro-drug with their application. 8
b) What do y understand abt the molecular docking? 7

7 a) Define pro-drug and advantages associated with pro-drug formation. 8
b) Explain abt HTS and its importance. 7

8 a) What is the role of nucleic acid and protein micro array in target discovery and
validation. 10
b) Write a note on economy of drug discovery.
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