Download OU M.Pharma Pharmacology 2nd Sem 2018 1214 Pharmacological And Toxicological Screening Methods Ii Question Paper

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CODE:1214/PClI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmacology) II-Semester (PCI) Main Examination, August 2018

Subject : Pharmacological and Toxicological Screening Methods-II

Time : 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. Write in detail on OECD guidelines for conducting toxicity studies. 15

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2. (a) Describe in detail the flow chart of Preclinical studies. 10
   (b) Explain the dermal toxicity studies. 5
3. Write abt the importance & Application of toxico kinetics. 15
4. (a) Write in detail abt safety pharmacology. 8
   (b) Discuss in brief tier —I safety pharmacology studies 7

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5. Discuss in detail the importance of ICH guidelines for toxicity studies. 15
6. Write a note on (a) The principles of regulatory toxicology. 7
   (b) Alternative to animal models in preclinical toxicology studies. 8
7. (a) Write abt the risk assessment in male reproductive toxicity. 8
   (b) Explain the single dose and repeat dose toxicity studies as per OECD guidelines 7

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8. (a) Discuss in detail abt IND studies 8
   (b) Write a note on determination of LD 5o as per OECD- 423 guidelines 7