Download OU M.Pharma Pharmacology 2nd Sem 2019 13173PCI Principles Of Drug Discovery Question Paper

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Code No: 13173/PCI

FACULTY OF PHARMACY

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M. Pharmacy (Pharmacology) II-Semester (PCI) (Suppl.) Examination, February 2019

Subject: Principles of Drug Discovery

Time: 3 Hrs Max. Marks : 75

Note: Answer any five questions. All questions carry equal marks.

1. a) Write a note on economics of drug discovery. (7)
   

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   b) Describe the role of zinc finger proteins in target identification and validation. (8)
2. a) Write a note on combinatorial chemistry. (8)
   b) Explain in brief about reporter gene assay. (7)
3. a) Write a note on drug likeness screening. (5)
   b) Explain in detail about rational drug design. (10)

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4. a) Write a note on rigid docking. (5)
   b) Describe in brief about QSAR. (10)
5. a) Write the significance of Prodrug design. (5)
   b) Describe about the COMFA and COMSIA. (10)
6. a) Explain in brief about role of bioinformatics in drug discovery. (6)
   

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   b) Describe the computational prediction of structure. (9)
7. a) Write a note on scintillation proximity assay. (6)
   b) Describe the concept of pharmacophore based screening. (9)
8. a) Write a note on statistical methods in QSAR. (8)
   b) Describe in brief about rational of Prodrug design. (7)

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