Download GTU BE/B.Tech 2019 Winter 6th Sem New 2160401 Advanced Molecular Biology Ii Question Paper

Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2019 Winter 6th Sem New 2160401 Advanced Molecular Biology Ii Previous Question Paper

1
Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER ? VI (New) EXAMINATION ? WINTER 2019
Subject Code: 2160401 Date: 04/12/2019

Subject Name: Advanced Molecular Biology-II

Time: 02:30 PM TO 05:00 PM Total Marks: 70

Instructions:

1. Attempt all questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

MARKS

Q.1 (a) What do you mean by mapping of genes? What is
significance of gene mapping?
03
(b) Explain trans splicing and alternative splicing. 04
(c) Describe the mechanism of lariat formation during
splicing process.
07

Q.2 (a) How do intercalating agents lead to mutations? 03
(b) Compare missense and non sense mutations. 04
(c) Explain base substitution mutation and its effects with
proper illustration.
07
OR
(c) Explain frameshift mutation and its effects with proper
illustration
07
Q.3 (a) Draw a neat diagram of retrovirus. 03
(b) Compare lytic and lysogenic life cycles of virus. 04
(c) Explain intragenic supression of mutation with proper
example.
07
OR
Q.3 (a) What is primer walking? 03
(b) What is gene replacement and gene targetting? 04
(c) Explain effect of Ultraviolet radiation on DNA. 07
Q.4 (a) What are transposable elements? Give its types. 03
(b) Explain structure of trp operon. 04
(c) Explain the process of assembly and maturation of T
phage in its host.
07
OR
Q.4 (a) What is catabolite repression? 03
(b) Explain principle of LM PCR. 04
(c) Explain Base Excision Repair in detail. 07
Q.5 (a) What are self splicing RNAs? 03
(b) Enlist different methods for regulation of metabolic
pathway. Explain any one in detail.
04
(c) Explain principle, mechanism and application of DNA
Fingerprinting technique.
07
OR

Q.5 (a) What is linkage disequillibrium? 03
(b) Write a note on retrotransposon. 04
(c) Explain positive regulation of lac operon. 07

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