Subject Code: 2143601
GUJARAT TECHNOLOGICAL UNIVERSITY
--- Content provided by FirstRanker.com ---
SEMESTER-IV(NEW) — EXAMINATION — SUMMER 2019
Subject Name: Medicinal Chemistry & Physio-pharmacology
Time: 02:30 PM TO 05:00 PM
Date: 17/05/2019
Total Marks: 70
--- Content provided by FirstRanker.com ---
Instructions:
- Attempt all questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1
--- Content provided by FirstRanker.com ---
- (a) Explain the process of “Docking” [03]
- (b) What are the different types of receptors ? [04]
- (c) Discuss how the Nuclear Receptors work. [07]
Q.2
- (a) Define “solubility” and “rate of dissolution” of a substance. [03]
- (b) What are the factors affecting the rate of solubility of a drug ? [04]
- (c) What is “Maximum Absorbable Dose” (MAD) ? [07]
--- Content provided by FirstRanker.com ---
Q.3
- (a) Draw a neat & labeled structure of Nephron. Mention the functions of kidney. [03]
- (b) Write a note on: (i). Anemia & Hematinics, (ii). Thrombolytics, (iii). Antiplatelet drugs. Give suitable examples. [04]
- (c) Write the synthesis of any two drugs describing the manufacturing process: (i). Tripellanamine HCI, (ii). Antazoline HCI, (iii). Chlorcyclizine HCI, (iv). Promithazine HCI [07]
OR
The model for biological response of an anti-allergic compound is given by the equation:
Log (1/C) = —0.30 (Tm) — 1.35 (Zor)* + 2.0 (Zo1) +0.39 (XHBD) - 0.75.
--- Content provided by FirstRanker.com ---
Q.4
--- Content provided by FirstRanker.com ---
- (a) What is Partition Co-efficient ? How is it determined ? [03]
- (b) Discuss Hammett Constant. pKa value of benzoic acid is 4.11, pKa value of 4-Nitrobenzoic acid is 3.41. Find the Hammett Constant (s) for the 4-Nitro substituent. [04]
- (c) What is Fragment Based Drug Design (FBDD)? Explain why FBDD leads to drugs with least side-effects. Four fragments A,B,C and D on screening, yielded a HIT molecule C-A. Show the steps involved. [07]
Q.5
- (a) What is the general equation for biological response of a 3D QSAR model ? [03]
- (b) Discuss Hansch first model and the improvement on the first model, for biological response. [04]
- (c) What are the different types of forces involved in Drug-Receptor interactions ? Discuss the role of Hydrophobic Forces in the interaction. [07]
OR
- (a) What are the characteristics of a “HIT” molecule ? [03]
- (b) Write a note on “Cell-based” assay in High Throughput Screening (HTS). [04]
- (c) Discuss in brief the 04 types of Reversible Enzyme Inhibitors. [07]
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
Q.3
- (a) Discuss the filing of Abbreviated New Drug Application (ANDA). [03]
- (b) Write the Structural Activity Relationship of Anilide class of local anesthetics [04]
- (c) Draw the schematic flow diagram for Drug Discovery Process and mark relevant stages. [07]
OR
--- Content provided by FirstRanker.com ---
Q.4
- (a) Write a note on (i). Antacid, (ii). Antihelicobacter pylori drugs. [03]
- (b) Write the synthesis of (i). Benzocaine, (ii). Lidocaine [04]
- (c) Write the SAR of H1 receptor Antihistamines. Give suitable examples wherever required. [07]
--- Content provided by FirstRanker.com ---
Q.5
- (a) Describe “Acidotic Diuretics” with suitable examples and MOA of any one drug. [03]
- (b) What are Anticoagulants and what are their classifications? Give suitable examples. Write the MOA of Sodium citrate anticoagulant. [04]
- (c) Describe “Loop & High Ceiling” Diuretics. What are its disadvantages?. Give two examples. Write the synthesis of any one drug. [07]
--- Content provided by FirstRanker.com ---
This download link is referred from the post: GTU BE 2019 Summer Question Papers || Gujarat Technological University
--- Content provided by FirstRanker.com ---