Download GTU BE/B.Tech 2019 Summer 4th Sem New 2143601 Medicinal Chemistry And Physio Pharmacology Question Paper

Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2019 Summer 4th Sem New 2143601 Medicinal Chemistry And Physio Pharmacology Previous Question Paper

1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ?IV(NEW) ? EXAMINATION ? SUMMER 2019
Subject Code:2143601 Date:17/05/2019
Subject Name: Medicinal Chemistry & Physio-pharmacology
Time: 02:30 PM TO 05:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

MARKS

Q.1 (a) Explain the process of ?Docking? 03
(b) What are the different types of receptors ?
Discuss how the Nuclear Receptors work.
04
(c) Define ?solubility? and ?rate of dissolution? of a substance.
What are the factors affecting the rate of solubility of a drug ?
What is ?Maximum Absorbable Dose? (MAD) ?

07

Q.2 (a) Draw a neat & labeled structure of Nephron. Mention the functions of kidney. 03
(b) Write a note on: (i). Anemia & Hematinics, (ii). Thrombolytics, (iii).
Antiplatelet drugs. Give suitable examples.
04
(c) Write the synthesis of any two drugs describing the manufacturing process: (i).
Tripellanamine HCl, (ii). Antazoline HCl, (iii). Chlorcyclizine HCl, (iv).
Promithazine HCl
07
OR
(c) The model for biological response of an anti-allergic compound is given by the
equation
Log (1/C) = -- 0.30 (??) ? 1.35 (??R)
2
+ 2.0 (??I)
+ 0.39 (?HBD) ? 0.75.

07
Q.3 (a) Discuss the filing of Abbreviated New Drug Application (ANDA). 03
(b) Write the Structural Activity Relationship of Anilide class of local anesthetics 04
(c) Draw the schematic flow diagram for Drug Discovery Process and mark
relevant stages.
07
OR
Q.3 (a) Write a note on (i). Antacid, (ii). Antihelicobacter pylori drugs. 03
(b) Write the synthesis of (i). Benzocaine, (ii). Lidocaine 04
(c) Write the SAR of H1 receptor Antihistamines. Give suitable examples
wherever required.
07
Q.4 (a) Describe ?Acidotic Diuretics? with suitable examples and MOA of any one
drug.
03
(b) What are Anticoagulants and what are their classifications? Give suitable
examples. Write the MOA of Sodium citrate anticoagulant.
04
(c) Describe ?Loop & High Ceiling? Diuretics. What are its disadvantages?. Give
two examples. Write the synthesis of any one drug.
07






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1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ?IV(NEW) ? EXAMINATION ? SUMMER 2019
Subject Code:2143601 Date:17/05/2019
Subject Name: Medicinal Chemistry & Physio-pharmacology
Time: 02:30 PM TO 05:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

MARKS

Q.1 (a) Explain the process of ?Docking? 03
(b) What are the different types of receptors ?
Discuss how the Nuclear Receptors work.
04
(c) Define ?solubility? and ?rate of dissolution? of a substance.
What are the factors affecting the rate of solubility of a drug ?
What is ?Maximum Absorbable Dose? (MAD) ?

07

Q.2 (a) Draw a neat & labeled structure of Nephron. Mention the functions of kidney. 03
(b) Write a note on: (i). Anemia & Hematinics, (ii). Thrombolytics, (iii).
Antiplatelet drugs. Give suitable examples.
04
(c) Write the synthesis of any two drugs describing the manufacturing process: (i).
Tripellanamine HCl, (ii). Antazoline HCl, (iii). Chlorcyclizine HCl, (iv).
Promithazine HCl
07
OR
(c) The model for biological response of an anti-allergic compound is given by the
equation
Log (1/C) = -- 0.30 (??) ? 1.35 (??R)
2
+ 2.0 (??I)
+ 0.39 (?HBD) ? 0.75.

07
Q.3 (a) Discuss the filing of Abbreviated New Drug Application (ANDA). 03
(b) Write the Structural Activity Relationship of Anilide class of local anesthetics 04
(c) Draw the schematic flow diagram for Drug Discovery Process and mark
relevant stages.
07
OR
Q.3 (a) Write a note on (i). Antacid, (ii). Antihelicobacter pylori drugs. 03
(b) Write the synthesis of (i). Benzocaine, (ii). Lidocaine 04
(c) Write the SAR of H1 receptor Antihistamines. Give suitable examples
wherever required.
07
Q.4 (a) Describe ?Acidotic Diuretics? with suitable examples and MOA of any one
drug.
03
(b) What are Anticoagulants and what are their classifications? Give suitable
examples. Write the MOA of Sodium citrate anticoagulant.
04
(c) Describe ?Loop & High Ceiling? Diuretics. What are its disadvantages?. Give
two examples. Write the synthesis of any one drug.
07






2

OR
Q.4 (a) What is Partition Co-efficient ?
How is it determined ?
03
(b) Discuss Hammett Constant.
pKa value of benzoic acid is 4.11, pKa value of 4-Nitrobenzoic acid is 3.41.
Find the Hammett Constant (?) for the 4-Nitro substituent.
04
(c) What is Fragment Based Drug Design (FBDD)?
Explain why FBDD leads to drugs with least side-effects.
Four fragments A,B,C and D on screening, yielded a HIT molecule C-A. Show
the steps involved.
07
Q.5 (a) What is the general equation for biological response of a 3D QSAR model ? 03
(b) Discuss Hansch first model and the improvement on the first model, for
biological response.
04
(c) What are the different types of forces involved in Drug-Receptor interactions
? Discuss the role of Hydrophobic Forces in the interaction.
07
OR

Q.5 (a) What are the characteristics of a ?HIT? molecule ? 03
(b) Write a note on ?Cell-based? assay in High Throughput Screening (HTS). 04
(c) Discuss in brief the 04 types of Reversible Enzyme Inhibitors. 07

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