Download GTU BE/B.Tech 2019 Summer 6th Sem New 2160410 Bioinformatics Question Paper

Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2019 Summer 6th Sem New 2160410 Bioinformatics Previous Question Paper

1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ?VI(NEW) ? EXAMINATION ? SUMMER 2019
Subject Code:2160410 Date:21/05/2019
Subject Name: Bioinformatics
Time:10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Give the historical overview of Bioinformatics. 03
(b) What is consensus sequence? 04
(c) Briefly explain the role of NCBI. Further, discuss MMDB. 07

Q.2 (a) Enlist the tools of Entrez. 03
(b) Write with an example: global alignment. 04
(c) Discuss the importance of molecular biology in understanding bioinformatics. 07
OR
(c) For what attributes, do the phylogenetic analysis help? 07
Q.3 (a) What is cladistics and systemics? 03
(b) How is the score calculated for BLAST and transition-transversion matrices? 04
(c) Explain the terms: target identification and validation, lead molecule identification
and optimization.
07
OR
Q.3 (a) Describe Hidden Markov Model. 03
(b) Narrate the major features of PDB. 04
(c) Give the importance of multiple sequence alignment. 07
Q.4 (a) Write the steps of Chau-Fasman method for secondary structure prediction. 03
(b) What is DNA microarray? 04
(c) Make a clear list of applications of Bioinformatics and briefly important of all. 07
OR
Q.4 (a) Make a list of all the tools for gene prediction. 03
(b) Discuss maximum parsimony method representing phylogeny. 04
(c) What are the major tools or techniques in proteomics? Explain any two of them. 07
Q.5 (a) ?Protein structure is related with its function?. Discuss briefly. 03
(b) Write the steps for GOR IV method. 04
(c) What is Single nucleotide polymorphism? Explain. 07
OR
Q.5 (a) Define: Progressive alignment. 03
(b) What is clinical trial? What are its phases? 04
(c) Explain the types of proteomics studies, based on their characteristics. 07

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