Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2019 Summer 6th Sem New 2163601 Medicinal Chemistry I Previous Question Paper
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ? VI(NEW) ? EXAMINATION ? SUMMER 2019
Subject Code: 2163601 Date: 18/05/2019
Subject Name: Medicinal Chemistry-I
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) Write the mode of action (MOA) of Mono Amino Oxidase (MAO)
inhibitor Antidepressant. Give one example with its structure.
03
(b) Write the MOA & Structural Activity Relationship (SAR) of
Barbiturate class of Anticonvulsants. Illustrate with examples with
structures wherever required.
04
(c) Write the SAR of sympathomimetic drugs which contain a ?-phenyl
ethyl amine as parent structure. Illustrate with suitable examples.
07
Q.2 (a) Write the biosynthesis of Adrenaline & Noradrenaline. 03
(b) Explain ?Parkinsonism?. Write any two probable cause of this disease.
Write the classification of Antiparkinsonism agents with suitable
examples.
04
(c) Explain Hyperlipidaemia. Write the classification of
Antihyperlipidaemic agents with suitable examples. Write the MOA,
metabolism & synthesis of any one Fibric acid derivative
antihyperlipidaemic agent.
07
OR
(c) What are the classification of Adrenergic drugs based on their
structure.. Write the synthesis of any one drug in each class.
07
Q.3 (a) Write a note on with examples : (1). Emetics, (2). Antiemetics, (3).
Cardiovascular drugs.
03
(b) Describe the following drugs with one synthesis: (1). Inhalation
anaesthetics, (2). Intravenous anaesthetics
04
(c) Write the MOA of Tricyclic antidepressant. Write the synthesis of
Imipramine. (Structure given).
07
OR
Q.3 (a) Define Osteoporosis. Write a note on risk factors in female gender.
Give two examples of Ant Osteoporotic drugs.
03
(b) Describe basal anaesthetic, its advantages. Give synthesis of any one
drug.
04
(c) Write a note on Renin-Angiotensin Pathway. Write the synthesis of
(1). Hydralazine HCl & (2). Methyl Dopa.
07
Q.4 (a) Write a note on with suitable examples: (1). Sedatives & Hypnotics,
(2). Cardiac Glycosides.
03
(b) Write the MOA & metabolism of any one Antiparkinsonism agent. 04
(c) Describe the regulation of Catecholamines with appropriate structures. 07
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1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ? VI(NEW) ? EXAMINATION ? SUMMER 2019
Subject Code: 2163601 Date: 18/05/2019
Subject Name: Medicinal Chemistry-I
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) Write the mode of action (MOA) of Mono Amino Oxidase (MAO)
inhibitor Antidepressant. Give one example with its structure.
03
(b) Write the MOA & Structural Activity Relationship (SAR) of
Barbiturate class of Anticonvulsants. Illustrate with examples with
structures wherever required.
04
(c) Write the SAR of sympathomimetic drugs which contain a ?-phenyl
ethyl amine as parent structure. Illustrate with suitable examples.
07
Q.2 (a) Write the biosynthesis of Adrenaline & Noradrenaline. 03
(b) Explain ?Parkinsonism?. Write any two probable cause of this disease.
Write the classification of Antiparkinsonism agents with suitable
examples.
04
(c) Explain Hyperlipidaemia. Write the classification of
Antihyperlipidaemic agents with suitable examples. Write the MOA,
metabolism & synthesis of any one Fibric acid derivative
antihyperlipidaemic agent.
07
OR
(c) What are the classification of Adrenergic drugs based on their
structure.. Write the synthesis of any one drug in each class.
07
Q.3 (a) Write a note on with examples : (1). Emetics, (2). Antiemetics, (3).
Cardiovascular drugs.
03
(b) Describe the following drugs with one synthesis: (1). Inhalation
anaesthetics, (2). Intravenous anaesthetics
04
(c) Write the MOA of Tricyclic antidepressant. Write the synthesis of
Imipramine. (Structure given).
07
OR
Q.3 (a) Define Osteoporosis. Write a note on risk factors in female gender.
Give two examples of Ant Osteoporotic drugs.
03
(b) Describe basal anaesthetic, its advantages. Give synthesis of any one
drug.
04
(c) Write a note on Renin-Angiotensin Pathway. Write the synthesis of
(1). Hydralazine HCl & (2). Methyl Dopa.
07
Q.4 (a) Write a note on with suitable examples: (1). Sedatives & Hypnotics,
(2). Cardiac Glycosides.
03
(b) Write the MOA & metabolism of any one Antiparkinsonism agent. 04
(c) Describe the regulation of Catecholamines with appropriate structures. 07
2
OR
Q.4 (a) Write one example & MOA of antiepileptic drugs: (1) GABA
analogue, (2). Benzodiazepine derivative.
03
(b) Write the SAR of Phenothiazine derivative Tranquilizer. 04
(c) Write the synthesis of Acetylcholine. Write the SAR of Cholinergic
drugs.
07
Q.5 (a) What is an antiarrhythmic drug? Write its classifications with one
example in each classification.
03
(b) Write the MOA of antipsychotic drugs: (1). Meprobamate, (2).
Chlorpramazine
04
(c) Write the MOA & SAR of benzodiazepine class of sedatives &
hypnotics.
07
OR
Q.5 (a) Describe with example: (1) Selective Serotonin receptor inhibitor
antidepressant, (2). Selective Norepinephrine receptor inhibitor
antidepressant.
03
(b) Write the MOA & metabolism of any one HMG-CoA reductase
inhibitor Anticholesterol drug.
04
(c) Write the SAR & MOA of barbiturate class of sedatives & hypnotics 07
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This post was last modified on 20 February 2020