Subject Code: 2163605
Subject Name: Technology of Solid Dosage forms & Medicinal Natural Products
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GUJARAT TECHNOLOGICAL UNIVERSITY
SEMESTER-VI(NEW) — EXAMINATION — SUMMER 2019
Date: 21/05/2019
Time: 10:30 AM TO 01:00 PM
Total Marks: 70
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Instructions:
- Attempt all questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Briefly mention the side effects of alkaloid- Hyoscyamine on human body | MARKS 03 |
(b) Write a note on supercritical fluid extraction. Mention the advantages of Carbon dioxide. | 04 |
(c) Describe how Phenylalanine and Tyrosine are made from Shikkimic acid pathway biosynthetically | 07 |
Q.2 (a) Write a short note on Extraction of drug mentioning the steps involved in extraction process. | 03 |
(b) Write short notes on (i). Countercurrent extraction, (ii). Comminution | 04 |
(c) Describe Morphological, Chemical & Chemo-taxonomical classifications of drug. | 07 |
OR | |
Q.3 (a) Enlist the method of microencapsulation. Explain in detail air suspension method | 07 |
(b) Differentiate between Hard & soft gelatin capsule | 03 |
(c) Write a note on sugar coating of tablet | 04 |
Q.3 (a) Describe isolation of (i).Nicotine & (2).Bromolain | 07 |
OR | |
(b) List out the uses of TLC in phytochemical analysis of herbal drugs | 03 |
(c) Illustrate briefly how steroid (Lanosterol) is made biosynthetically from mevalonate pathway? | 04 |
Q4 (a) Enlist quality control test of tablets and describe disintegration test in detail | 07 |
(b) Mention: (i). an example of Lignan, (ii). Any two tests for detecting cardiac glycoside.(iii).the secondary metabolite in plants | 03 |
(c) What is microencapsulation? Give the advantages of microencapsulation | 04 |
Q4 (a) Define tablet and describe various method of granulation | 07 |
OR | |
(b) Suggest a method for the conversion of Morphine to Codeine | 03 |
(c) Write in brief about gelatin manufacturing process along with the types of gelatin | 07 |
Q.S (a) Explain Maceration, Infusion, Digestion and Decoction | 03 |
(b) Describe the synthesis of menthol | 04 |
(c) What are the defects of tablet coating. Explain. | 07 |
Q.5 (a) What are the types of tablet coating | 03 |
(b) Briefly describe the role of genetic marker in herbal drug technology. | 04 |
(c) Draw a neat-labeled diagram of the layout of tablet manufacturing facility. Describe each section in brief. | 07 |
Q.5 Describe the isolation of two antineoplastic drugs derived from Periwinkle plant | 07 |
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