Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2018 Winter 4th Sem New 2143601 Medicinal Chemistry And Physio Pharmacology Previous Question Paper
1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ?IV (NEW) EXAMINATION ? WINTER 2018
Subject Code:2143601 Date:05/12/2018
Subject Name:Medicinal Chemistry & Physio-pharmacology
Time: 02:30 PM TO 05:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) What is Partition Co-efficient ?
How is it determined ?
03
(b) What are the different types of receptors ?
Discuss how the Nuclear Receptors work.
04
(c) Write the synthesis of any two drugs describing the manufacturing process:
(i). Tripellanamine HCl, (ii). Antazoline HCl, (iii). Chlorcyclizine HCl, (iv).
Promithazine HCl
07
Q.2 (a) Draw a neat & labeled structure of Nephron. Mention the functions of
kidney.
03
(b) Discuss Hammett Constant.
pKa value of benzoic acid is 4.11, pKa value of 4-Nitrobenzoic acid is 3.41.
Find the Hammett Constant (?) for the 4-Nitro substituent.
04
(c) What is Fragment Based Drug Design (FBDD)?
Explain why FBDD leads to drugs with least side-effects.
Four fragments A,B,C and D on screening, yielded a HIT molecule C-A.
Show the steps involved.
07
OR
(c) Define ?solubility? and ?rate of dissolution? of a substance.
What are the factors affecting the rate of solubility of a drug ?
What is ?Maximum Absorbable Dose? (MAD) ?
07
Q.3 (a) What are the characteristics of a ?HIT? molecule ? 03
(b) Discuss Hansch first model and the improvement on the first model, for
biological response.
04
(c) Discuss in brief the 04 types of Reversible Enzyme Inhibitors. 07
OR
Q.3 (a) Explain the process of ?Docking? 03
(b) Write a note on ?Cell-based? assay in High Throughput Screening (HTS). 04
(c) Explain the SAR of Anilide class of Local anesthetics with suitable
examples wherever necessary.
07
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1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ?IV (NEW) EXAMINATION ? WINTER 2018
Subject Code:2143601 Date:05/12/2018
Subject Name:Medicinal Chemistry & Physio-pharmacology
Time: 02:30 PM TO 05:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) What is Partition Co-efficient ?
How is it determined ?
03
(b) What are the different types of receptors ?
Discuss how the Nuclear Receptors work.
04
(c) Write the synthesis of any two drugs describing the manufacturing process:
(i). Tripellanamine HCl, (ii). Antazoline HCl, (iii). Chlorcyclizine HCl, (iv).
Promithazine HCl
07
Q.2 (a) Draw a neat & labeled structure of Nephron. Mention the functions of
kidney.
03
(b) Discuss Hammett Constant.
pKa value of benzoic acid is 4.11, pKa value of 4-Nitrobenzoic acid is 3.41.
Find the Hammett Constant (?) for the 4-Nitro substituent.
04
(c) What is Fragment Based Drug Design (FBDD)?
Explain why FBDD leads to drugs with least side-effects.
Four fragments A,B,C and D on screening, yielded a HIT molecule C-A.
Show the steps involved.
07
OR
(c) Define ?solubility? and ?rate of dissolution? of a substance.
What are the factors affecting the rate of solubility of a drug ?
What is ?Maximum Absorbable Dose? (MAD) ?
07
Q.3 (a) What are the characteristics of a ?HIT? molecule ? 03
(b) Discuss Hansch first model and the improvement on the first model, for
biological response.
04
(c) Discuss in brief the 04 types of Reversible Enzyme Inhibitors. 07
OR
Q.3 (a) Explain the process of ?Docking? 03
(b) Write a note on ?Cell-based? assay in High Throughput Screening (HTS). 04
(c) Explain the SAR of Anilide class of Local anesthetics with suitable
examples wherever necessary.
07
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2
Q.4 (a) Write a note on (i). Antacid, (ii). Antihelicobacter pylori drugs. 03
(b) What are Anticoagulants and what are their classifications? Give suitable
examples. Write the MOA of Sodium citrate anticoagulant.
04
(c) Draw the schematic flow diagram for Drug Discovery Process and mark
relevant stages.
07
OR
Q.4 (a) Describe ?Acidotic Diuretics? with suitable examples and MOA of any one
drug.
03
(b) Write the synthesis of (i). Benzocaine, (ii). Lidocaine. 04
(c) What are the different types of forces involved in Drug-Receptor
interactions ? Discuss the role of Hydrophobic Forces in the interaction
07
Q.5 (a) What is the general equation for biological response of a 3D QSAR model
?
03
(b) Write a note on: (i). Anemia & Hematinics, (ii). Thrombolytics, (iii).
Antiplatelet drugs. Give suitable examples
04
(c) Describe ?Loop & High Ceiling? Diuretics. What are its disadvantages?.
Give two examples. Write the synthesis of any one drug.
07
OR
Q.5 (a) Discuss the filing of Abbreviated New Drug Application (ANDA). 03
(b) Write the synthesis of anticoagulant drug-Warfarin. Write its MOA. 04
(c) Write the SAR of H1 receptor Antihistamines. Give suitable examples
wherever required.
07
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This post was last modified on 20 February 2020