GTU BE/B.Tech 2018 Winter Question Papers || Gujarat Technological University
Subject Name:Medicinal Chemistry & Physio-pharmacology
Time: 02:30 PM TO 05:00 PM Total Marks: 70
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER-1V (NEW) EXAMINATION - WINTER 2018
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Subject Code:2143601 Date:05/12/2018Subject Name:Medicinal Chemistry & Physio-pharmacology
Time: 02:30 PM TO 05:00 PM Total Marks: 70
Instructions:
- Attempt all questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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| MARKS | ||
| Q.1 | (a) What is Partition Co-efficient ? How is it determined ? | 03 |
| (b) What are the different types of receptors ? Discuss how the Nuclear Receptors work. | 04 | |
| (c) Write the synthesis of any two drugs describing the manufacturing process: (1). Tripellanamine HCI, (i1). Antazoline HCI, (iii). Chlorcyclizine HCI, (iv). Promithazine HC] | 07 | |
| Q.2 | (a) Draw a neat & labeled structure of Nephron. Mention the functions of kidney. | 03 |
| (b) Discuss Hammett Constant. pKa value of benzoic acid is 4.11, pKa value of 4-Nitrobenzoic acid is 3.41. Find the Hammett Constant (s) for the 4-Nitro substituent. | 04 | |
| (c) What is Fragment Based Drug Design (FBDD)? Explain why FBDD leads to drugs with least side-effects. Four fragments A,B,C and D on screening, yielded a HIT molecule C-A. Show the steps involved. | 07 | |
| OR | ||
| (c) Define “solubility” and “rate of dissolution” of a substance. What are the factors affecting the rate of solubility of a drug ? What is “Maximum Absorbable Dose” (MAD) ? | 07 | |
| Q.3 | (a) What are the characteristics of a “HIT” molecule ? | 03 |
| (b) Discuss Hansch first model and the improvement on the first model, for biological response. | 04 | |
| (c) Discuss in brief the 04 types of Reversible Enzyme Inhibitors. | 07 | |
| OR | ||
| Q.3 | (a) Explain the process of “Docking” | 03 |
| (b) Write a note on “Cell-based” assay in High Throughput Screening (HTS). | 04 | |
| (c) Explain the SAR of Anilide class of Local anesthetics with suitable examples wherever necessary. | 07 | |
| Q.4 | (a) What are Anticoagulants and what are their classifications? Give suitable examples. Write the MOA of Sodium citrate anticoagulant. | 04 |
| (b) Draw the schematic flow diagram for Drug Discovery Process and mark relevant stages. | 07 | |
| OR | ||
| Q.4 | (a) Describe “Acidotic Diuretics” with suitable examples and MOA of any one drug. | 03 |
| (b) Write the synthesis of (1). Benzocaine, (ii). Lidocaine. | 04 | |
| Q.5 | (a) What are the different types of forces involved in Drug-Receptor interactions ? Discuss the role of Hydrophobic Forces in the interaction | 07 |
| (b) What is the general equation for biological response of a 3D QSAR model ? | 03 | |
| (c) Write a note on: (i). Anemia & Hematinics, (i1). Thrombolytics, (iii). Antiplatelet drugs. Give suitable examples | 04 | |
| Q.5 | (a) Describe “Loop & High Ceiling” Diuretics. What are its disadvantages?. Give two examples. Write the synthesis of any one drug. | 07 |
| OR | ||
| (b) Discuss the filing of Abbreviated New Drug Application (ANDA). | 03 | |
| (c) Write the synthesis of anticoagulant drug-Warfarin. Write its MOA. | 04 | |
| (d) Write the SAR of H1 receptor Antihistamines. Give suitable examples wherever required. | 07 |
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