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GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER-V (NEW) EXAMINATION - WINTER 2018
Subject Code:2153601 Date:20/11/2018
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Subject Name:Pharmaceutical Chemistry
Time: 10:30 AM TO 01:00 PM Total Marks: 70
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Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
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3. Figures to the right indicate full marks.
| MARKS | ||
| Q.1 (a) | Write the Mode of Action (MOA) & Structural Activity Relationship (SAR) of Sulphonyl Urea class of oral hypoglycaemic drugs. | 03 |
| (b) | By synthon approach, suggest a scheme for the synthesis of HI-Antihistamine-Meclizine | 04 |
| (c) | Write the synthesis of (1R,2S)(-)Ephedrine by disconnection approach. Describe the separation of (1R,2S)(-) Ephedrine from the 4 isomeric mixtures obtained from the chemical synthesis. | 07 |
| Q.2 (a) | Write the classifications of hormones. | 03 |
| (b) | Suggest a commercial root for the synthesis of anticonvulsant drug Phensuximide which is having a 5 membered Pyrrolidine dione ring. | 04 |
| (c) | Write the synthesis of third generation Cephalosporin drug- Cefotaxime using 7-ACA | 07 |
| OR | ||
| (c) | Describe the chemical degradation of Penicillin | 07 |
| Q.3 (a) | Write down the general names and structures of steroids having 18, 19, 21 and 27 carbons. | 03 |
| (b) | What are the classifications of Androgens? What are the therapeutic uses of Androgens? Give two examples of Androgens with structure. | 04 |
| (c) | What are Hormonal Contraceptives? Describe the classifications of Oral contraceptive with suitable examples. | 07 |
| OR | ||
| Q.3 (a) | Write the structures of following: (1). 5B,19-nor-androst-3-one, (2). 11B,17a,21-trihydroxypregn-4-ene-3,20-dione. | 03 |
| (b) | Write the metabolism of Testosterone. | 04 |
| (c) | Write the SAR of Progesterones | 07 |
| Q.4 (a) | By disconnection approach, suggest a scheme for the synthesis of Isoproterenol | 03 |
| (b) | By disconnection approach arrive at the starting material for the organic synthesis of the Cis isomer of anti-cancer drug Combretastatin A-4. Discuss the strategies employed to get the Cis isomer | 04 |
| (c) | By disconnection approach, suggest a scheme for the synthesis of anti-malarial drug Chloroquine having a quinoline structure. | 07 |
| OR | ||
| Q.4 (a) | Write any four guidelines for choosing a disconnection in organic synthesis by synthon approach. Give suitable examples. | 03 |
| (b) | By disconnection approach arrive at a suitable scheme for the synthesis of Propranolol | 04 |
| (c) | By disconnection approach suggest a scheme for the synthesis of Antifungal Econozole | 07 |
| Q.5 (a) | What are the general causes for Iron deficiency? Discuss in brief the Iron preparations. | 03 |
| (b) | Briefly describe Calcium Homeostasis | 04 |
| (c) | Name the Thyroid hormones and write their functions. Write the synthesis of Thyroid drug-Levothyroxine. | 07 |
| OR | ||
| Q.5 (a) | What are Antithyroid drugs? Give two examples with structure | 03 |
| (b) | Write the metabolism of Oestrogens | 04 |
| (c) | Write the MOA & Synthesis of Oral anti-diabetic drug- Pioglitazone. | 07 |
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