Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2018 Winter 5th Sem New 2153601 Pharmaceutical Chemistry Previous Question Paper
1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ?V (NEW) EXAMINATION ? WINTER 2018
Subject Code:2153601 Date:20/11/2018
Subject Name:Pharmaceutical Chemistry
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) Write the Mode of Action (MOA) & Structural Activity
Relationship (SAR) of Sulphonyl Urea class of oral hypoglycaemic
drugs.
03
(b) By synthon approach, suggest a scheme for the synthesis of H1-
Antihistamine-Meclizine
04
(c) Write the synthesis of (1R,2S)(-)Ephedrine by disconnection
approach. Describe the separation of (1R,2S)(-) Ephedrine from the
4 isomeric mixtures obtained from the chemical synthesis.
07
Q.2 (a) Write the classifications of hormones. 03
(b) Suggest a commercial root for the synthesis of anticonvulsant drug
Phensuximide which is having a 5 membered Pyrrolidine dione ring.
04
(c) Write the synthesis of third generation Cephalosporin drug-
Cefotaxime using 7-ACA
07
OR
(c) Describe the chemical degradation of Penicillin 07
Q.3 (a) Write down the general names and structures of steroids having 18,
19, 21 and 27 carbons.
03
(b) What are the classifications of Androgens? What are the therapeutic
uses of Androgens? Give two examples of Androgens with structure.
04
(c) What are Hormonal Contraceptives? Describe the classifications of
Oral contraceptive with suitable examples.
07
OR
Q.3 (a) Write the structures of following: (1). 5 ?,19-nor-androst-3-one, (2).
11?,17? ,21-trihydroxypregn-4-ene-3,20-dione.
03
(b) Write the metabolism of Testosterone. 04
(c) Write the SAR of Progesterones 07
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1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER ?V (NEW) EXAMINATION ? WINTER 2018
Subject Code:2153601 Date:20/11/2018
Subject Name:Pharmaceutical Chemistry
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) Write the Mode of Action (MOA) & Structural Activity
Relationship (SAR) of Sulphonyl Urea class of oral hypoglycaemic
drugs.
03
(b) By synthon approach, suggest a scheme for the synthesis of H1-
Antihistamine-Meclizine
04
(c) Write the synthesis of (1R,2S)(-)Ephedrine by disconnection
approach. Describe the separation of (1R,2S)(-) Ephedrine from the
4 isomeric mixtures obtained from the chemical synthesis.
07
Q.2 (a) Write the classifications of hormones. 03
(b) Suggest a commercial root for the synthesis of anticonvulsant drug
Phensuximide which is having a 5 membered Pyrrolidine dione ring.
04
(c) Write the synthesis of third generation Cephalosporin drug-
Cefotaxime using 7-ACA
07
OR
(c) Describe the chemical degradation of Penicillin 07
Q.3 (a) Write down the general names and structures of steroids having 18,
19, 21 and 27 carbons.
03
(b) What are the classifications of Androgens? What are the therapeutic
uses of Androgens? Give two examples of Androgens with structure.
04
(c) What are Hormonal Contraceptives? Describe the classifications of
Oral contraceptive with suitable examples.
07
OR
Q.3 (a) Write the structures of following: (1). 5 ?,19-nor-androst-3-one, (2).
11?,17? ,21-trihydroxypregn-4-ene-3,20-dione.
03
(b) Write the metabolism of Testosterone. 04
(c) Write the SAR of Progesterones 07
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2
Progesterone
Q.4 (a) By disconnection approach, suggest a scheme for the synthesis of
Isoproterenol
03
(b) By disconnection approach arrive at the starting material for the
organic synthesis of the Cis isomer of anti-cancer drug
Combretastatin A-4. Discuss the strategies employed to get the Cis
isomer
04
(c) By disconnection approach, suggest a scheme for the synthesis of
anti-malarial drug Chloroquine having a quinoline structure.
07
OR
Q.4 (a) Write any four guidelines for choosing a disconnection in organic
synthesis by synthon approach. Give suitable examples.
03
(b) By disconnection approach arrive at a suitable scheme for the
synthesis of Propranolol
04
(c) By disconnection approach suggest a scheme for the synthesis of
Antifungal Econozole
07
Q.5 (a) What are the general causes for Iron deficiency? Discuss in brief the
Iron preparations.
03
(b) Briefly describe Calcium Homeostasis 04
(c) Name the Thyroid hormones and write their functions. Write the
synthesis of Thyroid drug-Levothyroxine.
07
OR
Q.5 (a) What are Antithyroid drugs? Give two examples with structure 03
(b) Write the metabolism of Oestrogens 04
(c) Write the MOA & Synthesis of Oral anti-diabetic drug-
Pioglitazone.
07
*******
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This post was last modified on 20 February 2020