Download GTU BE/B.Tech 2018 Winter 6th Sem New 2160401 Advanced Molecular Biology Ii Question Paper

Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2018 Winter 6th Sem New 2160401 Advanced Molecular Biology Ii Previous Question Paper

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Seat No.: ________ Enrolment No.___________

GUJARAT TECHNOLOGICAL UNIVERSITY

BE - SEMESTER ?VI (NEW) EXAMINATION ? WINTER 2018
Subject Code: 2160401 Date:16/11/2018

Subject Name: Advanced Molecular Biology-II

Time: 02:30 PM TO 05:00 PM Total Marks: 70

Instructions:

1. Attempt all questions.

2. Make suitable assumptions wherever necessary.

3. Figures to the right indicate full marks.

MARKS

Q.1 (a) What is significance of RNA splicing? 03
(b) Explain base substitution mutation with suitable illustration. 04
(c) What are transposable elements? Explain its basic structure. 07
Q.2 (a) Define the terms reversion and suppresion of mutation. 03
(b) Write a short note on base analogue mutagens. 04
(c) Explain positive regulation of lac operon 07
OR
(c) Explain negative regulation of lac operon. 07
Q.3 (a) What is significance of gene mapping? 03
(b) Explain regulation of replication at genomic level in eukaryotes 04
(c) Explain mismatch repair mechanism in detail. 07
OR
Q.3 (a) Explain primer walking. 03
(b) Explain any one mechanism of regulation of metabolic pathway. 04
(c) Explain intragenic supression mechanism. 07
Q.4 (a) What are post transcriptional controls? 03
(b) Explain attenuation mechanism. 04
(c) Explain lifecycle of T4 phage. 07
OR
Q.4 (a) What is alternative and trans splicing? 03
(b) Write a note on splicing errors. 04
(c) Explain splicing mechanism of nuclear mRNA. 07
Q.5 (a) What is lysogeny? Give example of any one virus which performs
lysogeny.
03
(b) What are integrons and retrotransposons? 04
(c) Explain the technique of DNA fingerprinting. 07
OR

Q.5 (a) Explain molecular basis of mutation. 03
(b) Draw structure of retrovirus. 04
(c) Explain short gun DNA sequencing approach. 07

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