Download GTU (Gujarat Technological University) BE/BTech (Bachelor of Engineering / Bachelor of Technology) 2018 Winter 3rd Sem New 2133601 Semester?Iii New Previous Question Paper
1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER?III (New) EXAMINATION ? WINTER 2018
Subject Code: 2133601 Date: 28/11/2018
Subject Name: Introduction to Medicinal Chemistry &
Biochemistry(Elective-I)
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) Define (1). Structure- Activity Relationship (SAR), (2).
Medicinal Chemistry, (3). Drug
03
(b) Describe protein biosynthesis 04
(c) Write the mode of action of Non-Steroidal Anti Inflammatory
drugs (NSAID). Write the synthesis, SAR & metabolism of any
one Salicylate NSAID.
07
Q.2 (a) Write the classifications, MOA of anti HIV drugs with one
example
03
(b) What are GMPs? Why GMP is important? What are the
responsibilities
04
(c) Define the term: Transamination. Discuss Urea cycle in detail. 07
OR
(c) What are hormones? Give the classification of hormones with
their functions
07
Q.3 (a) Describe Drug PKa concept. 03
(b) Write a note on Drug classification. 04
(c) Write the classifications with examples of anti-amoebic drugs.
Write the Synthesis of (i). Metronidazole, (ii). Diloxanide
Furoate. Write the MOA of any one drug.
07
OR
Q.3 (a) What are (1). Diagnostic agents, (2). Antiseptics, (3).
Disinfectants. Give one example for each category.
03
(b) What is the medical condition called ?Gout?? How the anti-gout
agents work?. Give suitable example with structures.
04
(c) Write the synthesis of (i). Ethambutol & (ii). Isoniazid. Write
the MOA & metabolism of any one drug.
07
Q.4 (a) Write the MOA & synthesis of any one Sulphonamide drug 03
(b) Describe the MOA & synthesis of any one alkylating agent anti-
neoplastic drug.
04
(c) Define drug metabolism. Write its importance. Describe the
pathways with suitable example.
07
OR
Q.4 (a) What are the classifications of Azole class of antifungal agents?
Give one example in each class & Write the MOA of Azole
antifungal agents.
03
(b) What are the limitation in Cancer chemotherapy. Write a note
on anticancer drug derived from plants. Write the MOA of any
one drug.
04
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1
Seat No.: ________ Enrolment No.___________
GUJARAT TECHNOLOGICAL UNIVERSITY
BE - SEMESTER?III (New) EXAMINATION ? WINTER 2018
Subject Code: 2133601 Date: 28/11/2018
Subject Name: Introduction to Medicinal Chemistry &
Biochemistry(Elective-I)
Time: 10:30 AM TO 01:00 PM Total Marks: 70
Instructions:
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
MARKS
Q.1 (a) Define (1). Structure- Activity Relationship (SAR), (2).
Medicinal Chemistry, (3). Drug
03
(b) Describe protein biosynthesis 04
(c) Write the mode of action of Non-Steroidal Anti Inflammatory
drugs (NSAID). Write the synthesis, SAR & metabolism of any
one Salicylate NSAID.
07
Q.2 (a) Write the classifications, MOA of anti HIV drugs with one
example
03
(b) What are GMPs? Why GMP is important? What are the
responsibilities
04
(c) Define the term: Transamination. Discuss Urea cycle in detail. 07
OR
(c) What are hormones? Give the classification of hormones with
their functions
07
Q.3 (a) Describe Drug PKa concept. 03
(b) Write a note on Drug classification. 04
(c) Write the classifications with examples of anti-amoebic drugs.
Write the Synthesis of (i). Metronidazole, (ii). Diloxanide
Furoate. Write the MOA of any one drug.
07
OR
Q.3 (a) What are (1). Diagnostic agents, (2). Antiseptics, (3).
Disinfectants. Give one example for each category.
03
(b) What is the medical condition called ?Gout?? How the anti-gout
agents work?. Give suitable example with structures.
04
(c) Write the synthesis of (i). Ethambutol & (ii). Isoniazid. Write
the MOA & metabolism of any one drug.
07
Q.4 (a) Write the MOA & synthesis of any one Sulphonamide drug 03
(b) Describe the MOA & synthesis of any one alkylating agent anti-
neoplastic drug.
04
(c) Define drug metabolism. Write its importance. Describe the
pathways with suitable example.
07
OR
Q.4 (a) What are the classifications of Azole class of antifungal agents?
Give one example in each class & Write the MOA of Azole
antifungal agents.
03
(b) What are the limitation in Cancer chemotherapy. Write a note
on anticancer drug derived from plants. Write the MOA of any
one drug.
04
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2
(c) Explain in detail-Role of Vitamin as Coenzyme. 07
Q.5 (a) Discuss Photosynthesis in detail 03
(b) What are Anthelminitics? Give one example with structure of
any one Benzimidazole anthelminitics. Write its MOA &
metabolism.
04
(c) What is Glycolysis? Explain Glycolysis in detail with ATP
synthesis
07
OR
Q.5 (a) Describe the viral life cycle. 03
(b) Write the SAR of 4-aminoquinoline antimalarial drugs. Give
suitable examples.
04
(c) Draw a neat labeled structure of Eukaryotic cell. Describe the
function of cell organelles.
07
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This post was last modified on 20 February 2020