Download VNSGU MBBS 2010 1st Year RO 1545 R Biochemistry Paper I Question Paper

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RO-1545-R

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First Year M.B.B.S. Examination

June - 2010

Biochemistry (Paper - I)

Time : 2 Hours]

[Total Marks : 50

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Instructions:

1. Fill up strictly the details of &, signs on your answer book.
2. Figures to the right indicate full marks.
3. Draw diagrams where appropriate.

1. Write down different types of protein structures. How are different structures of protein stabilized?

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OR

1. Describe Haem synthesis and its regulation, enumerate porphyrias.

2. Read the following case and answer the following questions:

A three day old neonate was brought to pediatric nursery with yellow discoloration of sclera and skin. His total bilirubin was 9 mg/dl (Normal range: 0.1-1.0 mg/dl). Pediatrician diagnosed as a case of physiological jaundice. The patient was advised phototherapy and recovered in 24 hrs.

1. What is the cause of physiological jaundice?

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2. What is the difference between direct and indirect bilirubin?
3. What is the role of phototherapy in this case?
4. What are other causes of unconjugated hyperbilirubinemia?
5. What type of hyperbilirubinemia is seen in obstructive jaundice?

3. Write short notes on: (any three)

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1. Lysosomes and Peroxisomes
2. ELISA
3. Eicosanoids
4. Applications of radioisotopes in medicine
5. Bile salts.

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4. Write notes on: (any two)

1. Functions of plasma proteins
2. Mucopolysaccharides
3. Electrophoresis
4. Structure of collagen.

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5. Comment on / justify in 2-3 sentences: (any five)

1. Sucrose is a non-reducing disaccharide.
2. HDL cholesterol is "Good cholesterol".
3. Allopurinol is used in the treatment of gout.
4. Denaturation of proteins in food is biologically advantageous.

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5. Glucose is required for the absorption of Na+.
6. Proline does not allow forming alpha helix.
7. Selective COX2 inhibitors reduce gastric side effects of NSAIDS.

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