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RO-1545-R
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First Year M.B.B.S. Examination
June - 2010
Biochemistry (Paper - I)
Time : 2 Hours]
[Total Marks : 50
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Instructions:
- Fill up strictly the details of &, signs on your answer book.
- Figures to the right indicate full marks.
- Draw diagrams where appropriate.
1. Write down different types of protein structures. How are different structures of protein stabilized?
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OR
1. Describe Haem synthesis and its regulation, enumerate porphyrias.
2. Read the following case and answer the following questions:
A three day old neonate was brought to pediatric nursery with yellow discoloration of sclera and skin. His total bilirubin was 9 mg/dl (Normal range: 0.1-1.0 mg/dl). Pediatrician diagnosed as a case of physiological jaundice. The patient was advised phototherapy and recovered in 24 hrs.
- What is the cause of physiological jaundice?
- What is the difference between direct and indirect bilirubin?
- What is the role of phototherapy in this case?
- What are other causes of unconjugated hyperbilirubinemia?
- What type of hyperbilirubinemia is seen in obstructive jaundice?
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3. Write short notes on: (any three)
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- Lysosomes and Peroxisomes
- ELISA
- Eicosanoids
- Applications of radioisotopes in medicine
- Bile salts.
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4. Write notes on: (any two)
- Functions of plasma proteins
- Mucopolysaccharides
- Electrophoresis
- Structure of collagen.
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5. Comment on / justify in 2-3 sentences: (any five)
- Sucrose is a non-reducing disaccharide.
- HDL cholesterol is "Good cholesterol".
- Allopurinol is used in the treatment of gout.
- Denaturation of proteins in food is biologically advantageous.
- Glucose is required for the absorption of Na+.
- Proline does not allow forming alpha helix.
- Selective COX2 inhibitors reduce gastric side effects of NSAIDS.
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