Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - May 2012
[Time: 3 Hours]
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[Max. Marks: 100]
ADVANCED PHARMACEUTICAL CHEMISTRY (ORG.)
PAPER II
(RS2 and RS3)
Q.P. CODE: 9232
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- a) Give an account of combinatorial chemistry with special reference to its application in drug discovery.
b) Define catalysis. Explain the importance of homogenous catalysis in the manufacture of drugs. - Explain the following reaction mechanisms and the application in synthesis. (a) Perkin condensation (b) Hoffmann rearrangement.
- Outline the mechanism and discuss the synthetic importance of the following (a) Wagner - Meerwein (b) Reimer - Tiemann reaction.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain with examples various pericyclic reactions.
- Explain sigmatropic rearrangement.
- Give an account of macro beads in new solid phase synthesis.
- Give an account of addition reactions at carbon-carbon multiple bonds.
- Discuss the neighboring group assistance in free radical reaction.
- Discuss the mechanism of Diel's Alder reaction and explain its significance in pharma chemistry.
- Explain the mechanism involved in sommelet rearrangement
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SHORT NOTES 2 X 5 = 10 Marks
- Cope rearrangement.
- Wolff rearrangement.
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