Rajah Jandhi University of Health Sciences
First Year M. Pharm Degree Examination - MAY 2016
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[Time: 3 Hours] [Max. Marks: 100]
Advanced Pharmaceutical Chemistry
(Revised Scheme 4)
Q.P. CODE: 9346
Your answers should be specific to the questions asked.
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Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Explain the formation, structure and stability of carbocations and give the mechanisms involved in Wagner-Meerwein and Trans-annular rearrangements.
- What is Sonochemistry? Enumerate the synthetic application and limitation of Microwave synthesis of organic chemistry.
- Comment on the reactivity and stability of nitrenes with suitable examples. Explain their role in Hoffmann reaction.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Write a note on Wolff rearrangement and Reimer-Tiemann rearrangement.
- Explain the mechanism of aromatic nucleophilic substitution reaction with suitable examples.
- Discuss the various types of reduction strategies and explain their applications.
- Write a note on applications of Retrosynthesis.
- Describe the synthetic value of enzyme support systems used in combinatorial methods.
- Explain the application of PTC in synthesis of heterocyclic compounds.
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SHORT NOTES 2 X 5 = 10 Marks
- Cope rearrangements
- Macro Beads in Solid-Phase synthesis
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This download link is referred from the post: RGUHS M.Pharm Last 10 Years 2011-2021 Previous Question Papers || Rajiv Gandhi University of Health Sciences
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