Download RGUHS M.Pharmacy First Year May 2016 9347 Medicinal Chemistry ? I Drug Design Revised Scheme 4 Question Paper

Rajahdaandhi University of Health Sciences

FirstRanker.com

First Year M. Pharm Degree Examination - May 2016

--- Content provided by‍ FirstRanker.com ---

[Time: 3 Hours]

Medicinal Chemistry – I (Drug Design)

(Revised Scheme 4)

Q.P. CODE: 9347

Your answers should be specific to the questions asked.

--- Content provided by‍ FirstRanker.com ---

Draw neat, labeled diagrams wherever necessary.

[Max. Marks: 100]

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

1. Explain various steps involved in developing a QSAR model and discuss the steric parameters used in a QSAR.
2. a) Explain the rational design of non-covalent and covalent binding enzyme inhibitors. (12+8)
   

   --- Content provided by​ FirstRanker.com ---

   b) Describe enzymes inhibitors as transition state analogs.
3. Write notes on:
   a) Conformational analysis
   b) Virtual screening
   c) Aromatase inhibitors
   

   --- Content provided by​ FirstRanker.com ---

   d) HIV-Protease inhibitor

SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. Discuss the design and development of prodrugs with two specific examples.
5. Give an account of various protein-ligand docking techniques and their importance in drug discovery.
6. Explain the different non-covalent forces involved in drug receptor interaction.

--- Content provided by‌ FirstRanker.com ---

7. Define the terms receptor, agonist, partial agonist and antagonist. Discuss drug-receptor interaction theories.
8. With suitable examples, explain the applications of recombinant DNA technology in pharmacy.
9. What is a lead molecule? Discuss the various stages involved in identification of a lead molecule.

SHORT NOTES 2 X 5 = 10 Marks

10. Write a note on development of t-PA as a therapeutic agents.

--- Content provided by​ FirstRanker.com ---

11. What is epitope mapping? Give the importance of epitope mapping in drug design.

*****