Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination – Nov 2011
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[Time: 3 Hours] [Max. Marks: 100]
MEDICINAL CHEMISTRY I (DRUG DESIGN)
PAPER III
(RS 2 & RS 3)
Q.P. CODE: 9233
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
2 X 20 = 40 Marks
LONG ESSAY (Answer any TWO)
- a) Explain the merits and de-merits of Hansch analysis and Free Wilson analysis. b) Explain in detail about enzyme inhibitors
- a) Explain the role of molecular modeling in drug design. b) Write a note on drug receptor interaction.
- a) Distinguish between proton pump inhibitors and H2 receptors blocker. b) Discuss in detail about Epitope mapping c) Explain drug metabolism with emphasis on "Stereochemical aspects"
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5 X 10 = 50 Marks
SHORT ESSAY (Answer any FIVE)
- Write the effect of bioisosterism and partition coefficient on biological activity
- Explain the pharmacokinetic objective in the design of prodrugs.
- Write a note on Rigid analogs.
- Write an account of Immuno stimulants
- Explain the complex events that follow the administration of drug orally.
- Outline the various strategies adopted in the design of anti-neoplastic drugs and with suitable examples
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2 X 5 = 10 Marks
SHORT NOTES
- Add a note on the application of free Wilson analysis
- Add a note on Immuno suppressive agents.
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