Download RGUHS (Rajiv Gandhi University of Health Sciences) M Pharma (Master of Pharmacy) First Year (1st Year) Nov 2011 9233 Medicinal Chemistry I Drug Design Paper Iii Rs 2 And Rs 3 Question Paper.
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? Nov 2011
[Time: 3 Hours] [Max. Marks: 100]
MEDICINAL CHEMISTRY I (DRUG DESIGN)
PAPER III
(RS 2 & RS 3)
Q.P. CODE: 9233
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
1. a) Explain the merits and de-merits of Hansch analysis and Free Wilson analysis.
b) Explain in detail about enzyme inhibitors
2. a) Explain the role of molecular modeling in drug design.
b) Write a note on drug receptor interaction.
3. a) Distinguish between proton pump inhibitors and H
2
receptors blocker.
b) Discuss in detail about Epitope mapping
c) Explain drug metabolism with emphasis on ?Stereochemical aspects?
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
4. Write the effect of bioisosterism and partition coefficient on biological activity
5. Explain the pharmacokinetic objective in the design of prodrugs.
6. Write a note on Rigid analogs.
7. Write an account of lmmuno stimulants.
8. Explain the complex events that following the administration of drug orally.
9. Outline the various strategies adopted in the design of anti-neoplastic drugs and with suitable
examples
SHORT NOTES 2 X 5 = 10 Marks
10. Add a note on the application of free Wilson analysis
11. Add a note on Immno suppressive agents.
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This post was last modified on 20 December 2019