RGUHS M.Pharm Last 10 Years 2011-2021 Previous Question Papers || Rajiv Gandhi University of Health Sciences
Rajah Jandhi University of Health Sciences
First Year M. Pharm Degree Examination - Oct/Nov 2014
[Time: 3 Hours]
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Medicinal Chemistry – I (Drug Design)
(Revised Scheme 4)
Q.P. CODE: 9347
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO)
2 X 20 = 40 Marks
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- Explain the design concept of any one enzyme inhibitor and classify enzyme inhibitors.
- Write short notes on:
- Receptor-Ligand interaction
- Receptor Binding Assays
- Functional Assays
- Receptor sources.
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- What do you mean by immune response? Explain the drugs affecting immune response.
SHORT ESSAY (Answer any FIVE)
5 X 10 = 50 Marks
- How will you explain relationship between physical properties and biological activity by using Hammet and Taft equations?
- Enumerate and explain computational Protein-Ligand Docking techniques.
- Describe the molecular modeling in drug design using lead optimization.
- Discuss the prodrugs of various functional groups.
- Explain Human growth hormone using t-PA development concept.
- Write a note on drug design and discovery.
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SHORT NOTES
2 X 5 = 10 Marks
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- Application of Free-Wilson analysis
- Topological Drug classification
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