Download RGUHS M.Pharmacy First Year 2014 November 9348 Medicinal Chemistry Ii Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka

First Year M. Pharm Degree Examination – Oct/Nov 2014

Time: Three Hours Max. Marks: 100 Marks

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MEDICINAL CHEMISTRY-II (Natural Products)

(Revised Scheme 4)

Q.P. CODE: 9348

Your answers should be specific to the questions asked.

Draw neat labeled diagrams wherever necessary

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LONG ESSAYS (Answer any Two) 2 x 20 = 40 Marks

1. a) Prove the structure of papaverine based on its chemical degradation and synthesis.
   b) Describe the chemistry and SAR of penicillins along with any one synthesis. (12+8)
2. a) Describe the chemistry, mechanism of action and classification of steroidal hormones. Add a note on carotenoids and their therapeutic importance
   b) Give proof for the structure of Morphine. (12+8)

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3. What are antibiotics? Describe how the ß lactamase stable cephalosporins were developed. Add a note on Clavulanic acid analogs.

SHORT ESSAYS (Answer any FIVE) 5 x 10 = 50 Marks

4. Elucidate the structure of Reserpine.
5. Illustrate the metabolism of Purines and Pyrimidines.
6. Illustrate the various reactions possible by microbial biotransformations.

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7. Elucidate the structure of emetine.
8. Discuss the Purine and Pyrimidine based antineoplastic and antiparasitic agents.
9. Provide evidence for the structure of Vit C.

SHORT NOTES 2 x 5 = 10 Marks

10. Discuss in detail the structure of vincristine and vinblastine.

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11. Describe the structural features and development of amido penicillins.

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