Download RGUHS (Rajiv Gandhi University of Health Sciences) M Pharma (Master of Pharmacy) First Year (1st Year) 2015 November 9243 Pharmacological Screening Methods And Clinical Evaluation Paper Iii Rs 2 And Rs 3 Question Paper.
Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? NOVEMBER 2015
[Time: 3 Hours] [Max. Marks: 100]
PHARMACOLOGICAL SCREENING METHODS
AND CLINICAL EVALUATION
PAPER III
(RS 2 & RS 3)
Q.P. CODE: 9243
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
1. a) Explain various mechanisms of drug transport across cell barrier with neat diagrams
b) Define receptor. Classify and discuss various types of receptors with neat diagrams
2. a) What is bioassay? Explain the bioassay of Insulin
b) Define transgenic animals. Discuss the importance of transgenic animals in drug screening
3. a) Discuss the various phases of clinical trials
b) Discuss the rational drug use
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
4. Null hypothesis and coefficient of variation
5. Variability in drug action due to age, sex and weight
6. Wilcoxon test and their application in drug research
7. Screening of antimalarial agents
8. Applications of cell lines in drug screening
9. Phase I and phase II metabolism of a drug
SHORT NOTES 2 X 5 = 10 Marks
10. Bioequivalence
11. ICMR guidelines
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This post was last modified on 20 December 2019