Rajiv Gandhi University of Health Sciences, Karnataka
I Year Pharm-D Examination – NOV 2016
Time: Three Hours Max. Marks: 70 Marks
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PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. CODE: 2854
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
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- a) What are alkenes? Give the rules for their nomenclature with examples.
b) Explain the addition of carbenes to alkenes. - What is meant by orientation and reactivity on aromatic rings? Discuss the orientation effect in nitrobenzene and chlorobenzene.
- Explain SN2 reactions with reference to
a) Mechanism b) Stereo chemistry c) Structure of substrate d) Role of solvents.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Define dehydrohalogenation. Write the reactivity and orientation in E1 reaction.
- Explain the mechanism involved in
a) Cannizzaro's reaction
b) Friedel-Craft's acylations - Give the synthesis, assay and uses of Sachharin
- Explain the basicity of Amines.
- Write a note on phase transfer catalysis.
- Giving mechanisms explain the Markonikov's rule and Anti-Markonikov's rule.
- Define acidity. Explain the effect of substituents on the acidity of the carboxylic acids.
- Give the synthesis and uses of Aspirin. How it is tested for the presence of free Salicylic acid?
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SHORT ANSWERS 10 x 2 = 20 Marks
- Define dipole moment. Why dipole moment of CCl4 is zero?
- What is Knoevengle's reaction? Give one example.
- Define protic and aprotic polar solvent with examples.
- Write the structure of (a) Methyl 4-oxopentanoate (b) 5-Amino-3-hexanol.
- What is optical isomerism? Give one example.
- Why boiling point of the o-Aminophenol is lesser than the P-Aminophenol?
- What is hyperconjugation? Give example.
- Give the structure and uses of
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a) Citric acid b) Tartaric acid - What is 1, 2-hydride shift? Give example.
- Define free radicals. Give examples.
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