Rajiv Gandhi University of Health Sciences, Karnataka
V Year Pharm-D (II Year Pharm D Post Baccalaureate) Degree Examination – NOV 2016
Time: Three Hours
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Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG MONITORING (RS)
Q.P. CODE: 2876
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
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LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
- Explain the pharmacokinetics of drugs in obese patients and describe the dosage adjustment in these patients with necessary examples.
- Define pharmacokinetic drug interactions. Explain the pharmacokinetic interactions of drugs with examples.
- List out the indications, necessity and process involved in TDM process. Write a note on TDM of Digoxin
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
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- Define the role of nomograms and tabulations in designing dosage regimen?
- Define polymorphism? Describe the genetic polymorphism in CYP 2D6 and CYP 2C9 enzymes
- Discuss about the dosage adjustment in patients with liver failure.
- Write a note on biliary excretion of drugs.
- Describe the TDM of carbamazepine
- Write a note on role of pharmacokineticist in TDM processes
- Calculate the creatinine clearance for 30 year old female patient with serum creatinine value of 0.8mg/dl. The patient is 5ft 1 inch height and weighs 69kg
- Mention the pharmacokinetic differences between geriatric and pediatric patients
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SHORT ANSWERS 10 x 2 = 20 Marks
- Write the significance of pharmacokinetic and pharmacodynamic correlation in drug therapy
- What is clinical pharmacokinetics and explain its importance
- Define hemodialysis. Give its significance.
- Define allele and variant allele
- Illustrate four pharmacokinetic interactions affecting the metabolism of drugs
- Enumerate the mechanism of drug interactions between clopidogrel and aspirin
- What is creatinine clearance? Give the formula with normal value.
- Give the indications which necessitate TDM for lithium.
- Mention hepatic biomarkers and write its normal values.
- Define GFR. Write the formula to calculate GFR with normal value.
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