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Rajiv Gandhi University of Health Sciences, Karnataka
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V Year Pharm-D (II Year Pharm D Post Baccalaureate) Degree Examination – NOVEMBER 2015
Time: Three Hours Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG MONITORING (RS)
Q.P. CODE: 2876
Your answers should be specific to the questions asked
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Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
- List various indications for TDM. Explain the necessity and process of TDM in patients receiving digoxin and phenytoin.
- a) Discuss the pharmacokinetic / pharmacodynamic correlation in drug therapy.
b) Explain the role of adaptive method in population pharmacokinetics. - Explain the process and clinical significance of conversion from intravenous to oral dosing.
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SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
- Explain the role of nomograms and tabulations in designing dosage regimen.
- Discuss the factors influencing drug dosing in pediatric patients.
- Describe the role of cytochrome P-450 Isoenzymes in drug interactions. Add a note with suitable examples and their clinical significance.
- Discuss analysis of population pharmacokinetic data.
- Describe the role of genetic polymorphism in drug targets.
- Define pharmacogenetics and with suitable examples and discuss inhibition of biliary excretions.
- Explain the methods of determining creatinine clearance
- Write a note on individualization of drug dosage regimen.
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SHORT ANSWERS 10 x 2 = 20 Marks
- Add a note on BEER's criteria for drugs to be used in geriatric patients.
- Importance of loading dose and elimination half life in finding drug dosing intervals.
- Significance of clinical pharmacokinetics
- Enumerate the mechanism of drug interactions between rifampicin and oral contraceptives.
- Drug dosage regimen in hepatic disorders
- Drug dosing in obese patients
- Hepatic clearance
- Drug dosing in dialysis patients
- With suitable examples, enumerate drug dosing in genetic dependent fast acetylators.
- Extracorporeal removal of drugs
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