Rajiv Gandhi University of Health Sciences, Karnataka
III Year Pharma-D Degree Examination – Mar 2013
Time: Three Hours Max. Marks: 70 Marks
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MEDICINAL CHEMSITRY
Q.P. CODE: 2865
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
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- Write a note on quinolones. Discuss structure activity relationships of quinolones and give the synthesis of ciprofloxacin.
- Discuss in detail anti-tubercular agents including classification and mechanism of action. Give the synthesis of any one anti-tubercular drug.
- Discuss prodrugs in detail with examples. Add a brief note on antisense molecules.
SHORT ESSAYS 6 x 5 = 30 Marks
- Write a note on antifungal antibiotics.
- Define and classify antiviral agents with examples.
- Give a brief note on computer aided drug design.
- Give an account of diagnostic agents.
- Write short notes on non-steroidal hormones.
- Give synthesis of any two antiprotozoal drugs.
- Write a note on antimetabolities used in cancer treatment.
- Classify antihypertensive agents with examples. Write the synthesis of hydralazine.
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SHORT ANSWERS 10 x 2 = 20 Marks
- Give the structure and uses of phenindione.
- Name two antihyperlipidemic agents with their chemical structure.
- Structure and uses of acetoazolamide
- Write the structure and uses of mebendazole.
- Name two short acting sulfonamides with structures.
- Structure and uses of primaquine
- Define Anticoagulants with one example.
- Structure and uses of any one cephalosporins.
- Properties of ideal preservative
- Applications of QSAR
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