Download RGUHS Pharm-D 5th Semester 2013 March 2876 Clinical Pharmacokinetics And Therapeutic Drug Monitoring Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharm.D (Doctor of Pharmacy) 5th Semester 2013 March 2876 Clinical Pharmacokinetics And Therapeutic Drug Monitoring Question Paper.

2876_2013_1_S222.doc
Rajiv Gandhi University of Health Sciences, Karnataka
V Year Pharma-D Post Baccalaureate Degree Examination ? Mar 2013

Time: Three Hours Max. Marks: 70 Marks

CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG
MONITORING

Q.P. CODE: 2876

Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
1.
Define TDM. Discuss the indications for TDM. Explain the role of clinical pharmacokinetist in
TDM of drugs
2.
Explain with suitable examples how the dose and elimination half life of a drug influence the
duration of activity
3
Define nomograms. Explain how they are useful in pharmacokinetic studies. What are their
advantages & disadvantages

SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
4.
Explain the principle of drug dosing in elderly
5.
Why phenytoin is a drug for TDM. Explain
6.
Explain the role of genetic polymorphism in drug metabolism. Give suitable examples
7.
Explain the NONMEM method of analysis of population pharmacokinetic data
8.
Explain briefly Hemodialysis
9.
Define pharmacokinetic drug interactions with examples. Add a note on effect of enzyme
induction on drug interaction
10.
Explain the different methods of determining glomerular filtration rate
11.
Define and explain Bayesian theory

SHORT ANSWERS 10 x 2 = 20 Marks
12.
How do you adjust dose of a drug in renal impairment with constant dosing interval
13.
Give examples of drug interactions affecting bioavailability of drugs
14.
Write the principle in converting IV dose to oral dose
15.
Child dose is not the same as adult dose. Why?
16.
Give examples of hepatic markers and their importance
17.
Explain a typical plot of pharmacologic response versus drug dose
18.
Enumerate four causes of renal dysfunction
19.
What is meant by dosing with feedback
20.
Write the factors influencing individualisation of drug dosage regimen
21.
Calculate creatinine clearance in an 85 year old female weighing 190 lbs, with serum
creatinine concentration of 1.5 mg/100ml

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