Rajiv Gandhi University of Health Sciences, Karnataka
V Year Pharma-D Post Baccalaureate Degree Examination – Mar 2013
Time: Three Hours
--- Content provided by FirstRanker.com ---
Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG MONITORING
Q.P. CODE: 2876
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
--- Content provided by FirstRanker.com ---
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
- Define TDM. Discuss the indications for TDM. Explain the role of clinical pharmacokinetist in TDM of drugs
- Explain with suitable examples how the dose and elimination half life of a drug influence the duration of activity
- Define nomograms. Explain how they are useful in pharmacokinetic studies. What are their advantages & disadvantages
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
--- Content provided by FirstRanker.com ---
- Explain the principle of drug dosing in elderly
- Why phenytoin is a drug for TDM. Explain
- Explain the NONMEM method of analysis of population pharmacokinetic data
- Explain the role of genetic polymorphism in drug metabolism. Give suitable examples
- Explain briefly Hemodialysis
- Define pharmacokinetic drug induction on drug interaction. Add a note on effect of enzyme
- Explain the different methods of determining glomerular filtration rate
--- Content provided by FirstRanker.com ---
SHORT ANSWERS 10 x 2 = 20 Marks
- How do you adjust dose of a drug in renal impairment with constant dosing interval
- Give examples of drug interactions affecting bioavailability of drugs
- Write the principle in converting IV dose to oral dose
- Child dose is not the same as adult dose. Why?
- Give examples of hepatic markers and their importance
- Explain a typical plot of pharmacologic response versus drug dose
- Enumerate four causes of renal dysfunction
- What is meant by dosing with feedback
- Write the factors influencing individualisation of drug dosage regimen
- Calculate creatinine clearance in an 85 year old female weighing 190 lbs, with serum creatinine concentration of 1.5 mg/100ml
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
*****
--- Content provided by FirstRanker.com ---
This download link is referred from the post: RGUHS Pharma-D Last 10 Years 2011-2021 Previous Question Papers || Rajiv Gandhi University of Health Sciences
--- Content provided by FirstRanker.com ---