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Rajiv Gandhi University of Health Sciences, Karnataka
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Fifth Year Pharma- D Post Baccalaureate Degree Examination – Feb/March 2011
Time: Three Hours
Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG MONITORING
Q.P. CODE: 2876
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Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any two)
2 x 10 = 20 Marks
- Explain in detail Hemodialysis
- Explain the various methods for estimating dosage regimens in uremic patients
- What is population pharmacokinetic data? Explain in detail the methods adopted in analysis of such data
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SHORT ESSAYS (Answer any six)
6 x 5 = 30 Marks
- Explain the role of liver enzymes in drug interactions with examples
- Explain the principle and method of dosage in geriatrics
- Explain the role of P-glycoprotein in bioavailability of drugs
- Define and explain Bayesian theory.
- Explain the TDM of Cyclosporin.
- Define and explain the significance of Pharmacokinetic drug interactions with examples.
- Explain the major considerations in TDM studies
- Explain how Renal and hepatic diseases affect protein binding of drugs. How are these changes accounted for dose adjustment?
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SHORT ANSWERS
10 x 2 = 20 Marks
- What is inulin clearance? Explain
- Explain the application of Nanograms
- Enumerate the different methods of designing dosage regimens
- Write the equation defining the relationship between dose and duration of activity for single iv bolus injection
- Define genetic polymorphism.
- Enumerate the factors affecting dialyzability of drugs
- Explain the various liver function tests and their significance
- What are the assumptions made when adjusting the dosage regimen based on creatinine clearance during renal failure
- Write the significance of Pharmacokinetic-Pharmacodynamic correlation.
- Calculate the creatinine clearance for a child (8 years, body length 122cm) whose serum creatinine value is 0.9 mg/dl.
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