Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharm.D (Doctor of Pharmacy) 5th Semester 2011 Feb 2876 Clinical Pharmacokinetics And Therapeutic Drug Monitoring Question Paper.
Rajiv Gandhi University of Health Sciences, Karnataka
Fifth Year Pharma- D Post Baccalaureate Degree Examination ? Feb/March 2011
Time: Three Hours Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG
MONITORING
Q.P. CODE: 2876
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
1.
Explain in detail Hemodialysis
2.
Explain the various methods for estimating dosage regimens in uremic patients
3
What is population pharmacokinetic data? Explain in detail the methods adopted in analysis
of such data
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
4.
Explain the role of liver enzymes in drug interactions with examples
5.
Explain the principle and method of dosage adjustment in geriatrics
6.
Explain the role of P-glylcoprotein in bioavailability of drugs
7.
Define and explain Bayesian theory.
8.
Explain the TDM of Cyclosporin.
9.
Define and explain the significance of Pharmacokinetic drug interactions with examples.
10.
Explain the major considerations in TDM studies
11.
Explain how Renal and hepatic diseases affect protein binding of drugs. How are these
changes accounted for dose adjustment?
SHORT ANSWERS 10 x 2 = 20 Marks
12.
What is inulin clearance? Explain
13.
Explain the application of Nanograms
14.
Enumerate the different methods of designing dosage regimens
15.
Write the equation defining the relationship between dose and duration of activity for single
iv bolus injection
16.
Define genetic polymorphism.
17.
Enumerate the factors affecting dailyzability of drugs
18.
Explain the various liver function tests and their significance
19.
What are the assumptions made when adjusting the dosage regimen based on creatinine
clearance during renal failure
20.
Write the significance of Pharmacokinetic-Pharmacodynamic correlation.
21.
Calculate the creatinine clearance for a child (8 years, body length 122cm) whose serum
creatinine value is 0.9 mg/dl.
*****
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2876_2011_1_S181.doc
Rajiv Gandhi University of Health Sciences, Karnataka
Fifth Year Pharma- D Post Baccalaureate Degree Examination ? Feb/March 2011
Time: Three Hours Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS & THERAPEUTIC DRUG
MONITORING
Q.P. CODE: 2876
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
1.
Explain in detail Hemodialysis
2.
Explain the various methods for estimating dosage regimens in uremic patients
3
What is population pharmacokinetic data? Explain in detail the methods adopted in analysis
of such data
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
4.
Explain the role of liver enzymes in drug interactions with examples
5.
Explain the principle and method of dosage adjustment in geriatrics
6.
Explain the role of P-glylcoprotein in bioavailability of drugs
7.
Define and explain Bayesian theory.
8.
Explain the TDM of Cyclosporin.
9.
Define and explain the significance of Pharmacokinetic drug interactions with examples.
10.
Explain the major considerations in TDM studies
11.
Explain how Renal and hepatic diseases affect protein binding of drugs. How are these
changes accounted for dose adjustment?
SHORT ANSWERS 10 x 2 = 20 Marks
12.
What is inulin clearance? Explain
13.
Explain the application of Nanograms
14.
Enumerate the different methods of designing dosage regimens
15.
Write the equation defining the relationship between dose and duration of activity for single
iv bolus injection
16.
Define genetic polymorphism.
17.
Enumerate the factors affecting dailyzability of drugs
18.
Explain the various liver function tests and their significance
19.
What are the assumptions made when adjusting the dosage regimen based on creatinine
clearance during renal failure
20.
Write the significance of Pharmacokinetic-Pharmacodynamic correlation.
21.
Calculate the creatinine clearance for a child (8 years, body length 122cm) whose serum
creatinine value is 0.9 mg/dl.
*****
2876_2011_1_S181.doc
Rajiv Gandhi University of Health Sciences, Karnataka
FirstRanker.com - FirstRanker's Choice
This post was last modified on 20 December 2019