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(LQ 4258) FEBRUARY 2020 Sub. Code: 4258
B.PHARM. DEGREE EXAMINATION
SECOND YEAR
PAPER III - ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY
O.P. Code: 564258
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Time: Three hours Maximum: 100 Marks
I. Elaborate on: (2x20=40)
- a) Explain stereochemistry of cyclic compounds.
b) Explain various methods of determination of configurations of geometric isomers. - a) Discuss chemistry and uses of ephedrine.
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b) Explain chemistry and medicinal uses of Vitamin B1 and Vitamin E.
II. Write notes on: (8x5=40)
- Define and explain pharmaceutical importance of chirality.
- Explain conformational analysis of 1, 2 dichloroethane.
- Explain various methods of resolution of racemic modification.
- Discuss the chemistry of imidazole.
- Explain chemistry and uses of thymol.
- Discuss chemistry of lanatoside.
- Explain chemistry of uric acid.
- Explain metal hydride reduction as synthetic tools.
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III. Short answers on: (10x2=20)
- What is Fischer projection?
- Define asymmetric synthesis.
- What is E-Z system of nomenclature?
- Write structure and medicinal uses of camphor.
- What are sennosides?
- Write structure and uses of folic acid.
- Write structure and medicinal uses of caffeine.
- Give medicinal uses of flavonoids.
- What is periodic acid oxidation?
- Give synthetic uses of hydrazine and its derivatives.
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