Download JNTUH Pharm D 5th Year PD503 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring Question Paper

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Time: 3hours Max.Marks:70
Answer any five questions
All questions carry equal marks
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1.a) What is clinical pharmacokinetics? Write its applications.
b) How will you determine frequency of drug administration? [7+7]

2.a) Why are the drugs administered in multiple doses? Explain with examples.
b) Explain the dose adjustments in obese patients? Discuss in brief the difficulties faced.

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[7+7]

3.a) Explain the pharmacokinetic drug interactions with suitable examples and mechanisms.
b) With suitable examples explain inhibition and induction of drug metabolism and their
significance in drug therapy. [7+7]

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4.a) Explain the term therapeutic drug monitoring? Describe different ways by which TDM is
achieved in individualized patients.
b) Discuss in brief TDM in cardiovascular diseases with relavant reasons. [7+7]

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5.a) Explain the methods of adjusting the dose and dosage regimen in patients with renal
disease.
b) Explain the difficulties in dose adjustment in patients with hepatic disease. [7+7]

6.a) Discuss the importance of population pharmacokinetics with suitable examples?

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b) Write in brief about Bayesian theory and its applications. [7+7]

7.a) What is pharmacogenitics? Discuss about genetic polymorphism in drug metabolism.
b) Write the implications of pharmacogenetics in pharmacokinetics of drugs. [7+7]

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8. Write note on the following:
a) Inhibition of biliary excretion
b) Extracorporeal removal of drugs. [7+7]

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