Rajiv Gandhi University of Health Sciences, Karnataka
III Year B. Pharm Degree Examination - 04-Jan-2020
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Time: Three Hours Max. Marks: 80 Marks
MEDICINAL CHEMISTRY - I (Revised Scheme - 2)
Q.P. CODE: 1961
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- What are the general pathways of drug metabolism and write the role of cytochrome P-450 in oxidative biotransformation.
- Outline the biosynthesis and metabolism of Acetylcholine. Explain the SAR of cholinergic
- What are antihistamines? Classify them with example. Discuss the SAR of H1 antagonists.
SHORT ESSAYS (Answer any Eight) 8 x 5 = 40 Marks
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- Write the SAR of barbiturates.
- Write the function, biosynthesis of adrenergic neurotransmitter.
- Write the role of solubility and protein binding in biological activity.
- Discuss the Eicosanoids biosynthesis.
- Write the mechanism of action of local anaesthetics. Write the synthesis of benzocaine.
- Classify general anaesthetics with example. Add a note on Dissociative Anaesthetics.
- Classify NSAIDs with example. Write the synthesis of Mefenamic acid.
- Classify sympathomimetic agents. Give one example for each class.
- Explain how partition coefficient and hydrogen bonding influences biological activity.
- Write the synthesis and uses of acetaminophen and physostigmine.
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SHORT ANSWERS 10 x 2 = 20 Marks
- Write the synthesis of Methsuximide.
- Write the synthesis of Diphenhydramine hydrochloride.
- What are anxiolytics? Give examples.
- Write the synthesis and uses of Glutethmide.
- Write the synthesis of Meclizine.
- Give the structure and name of drugs used in spasticity.
- Write the structure and use of Primidone.
- Write drugs used as Skeletal muscle relaxants.
- Write the structure and use of morphine.
- Sites of drug biotransformation
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