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1972 9999 S046
Rajiv Gandhi University of Health Sciences, Karnataka
IV Year B.Pharm Degree Examination — 24-Sep-2020
Time: Three Hours Max. Marks: 80 Marks
PHARMACOKINETICS & THERAPEUTIC DRUG MONITORING
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(Revised Scheme - 2)Q.P. CODE: 1972
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
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- Explain various physiological factors affecting drug absorption
- What do you understand by TDM? What is the criteria for valid TDM? Discuss the organization of a TDM service
- Discuss one compartment open model after IV bolus administration.
SHORT ESSAYS (Answer any Eight) 8 x 5 = 40 Marks
- Give the schematic representation of two and three compartment model
- Gastric emptying and its significance
- Protein binding and its clinical significance
- Methods of assessing bioavailability
- Assay methods in TDM study
- Concept of design of dosage regimen
- Dosing of drugs in elderly
- TDM of cyclosporine
- Renal and hepatic clearance
- Mono exponential disposition
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SHORT ANSWERS 10 x 2 = 20 Marks
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- Cross over design in bioequivalence studies
- Define organ clearance, renal clearance and hepatic clearance.
- Biological half life and its significance
- Apparent volume of distribution and its importance
- Area under the curve
- Need for TDM for Digoxin
- First order rate
- Give a diagrammatic representation of two compartment model for oral dosing.
- Accumulation index
- Relative and absolute Bioavailability
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This download link is referred from the post: RGUHS B.Pharm 4th Year 2020 Previous Question Papers - Rajiv Gandhi University of Health Sciences
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