Rajiv Gandhi University of Health Sciences, Karnataka
Fifth Semester B. Pharm Degree Examination - 02-Jan-2020
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Time: Three Hours Max. Marks: 75 Marks
MEDICINAL CHEMISTRY - I
Q.P. CODE: 5018
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
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LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- Classify antineoplastic agents with example. Outline the synthesis of Mercaptopurine and Methotrexate.
- Classify antihypertensive agents with examples? Write the MOA of Calcium channels blockers and give the synthesis of Isosorbide dinitrite.
- Classify local anaesthetic agents and discuss SAR of Benzoic acid and Anilide class of local anaesthetic agents with suitable examples.
SHORT ESSAYS (Answer any Seven) 7 x 5 = 35 Marks
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- Explain in detail about histamine receptors and their biological importance.
- What are potassium sparing diuretics? Outline the synthesis and medicinal uses of Chlorthiazide.
- Write a note on cardiac glycosides used in the treatment of Congestive Heart Failure.
- What are lipid lowering agents? Give the structure and uses of Lovastatin, Clofibrate and Cholesteramine.
- Classify antiarrhythmic agents with examples? Give the synthesis of Disopyramide.
- Discuss about the medicinal importance of Corticosteroids and give the structures and uses of any two Corticosteroids.
- Describe the chemistry of oral contraceptives.
- Write a note on antithyroid drugs and give the structure and uses of any two.
- What are hypoglycemic agents? Discuss about Glucosidase inhibitors as antidiabetic agents.
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SHORT ANSWERS (Answer All) 10 x 2 = 20 Marks
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- Write the structure and uses of any two aminoalkyl ether derivatives as antihistaminic
- Write the structure and uses of any two H2 antagonists.
- Explain mechanism of action of gastric proton pump inhibitors.
- Write briefly about nitro vasodilators.
- Discuss the mechanism of action of Acetazolamide.
- Outline the synthesis of furosemide.
- Write the structure and uses of any two anticoagulants.
- Outline the synthesis of Warfarin.
- Write the structure and uses of synthetic estrogens.
- Write the structure and uses of Meglitinide and chlorpropamide.
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This download link is referred from the post: RGUHS B.Pharm 1st Year 2020 Previous Question Papers - Rajiv Gandhi University of Health Sciences
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