Rajiv Gandhi University of Health Sciences, Karnataka
V Year Pharm-D (II Year Pharm D Post Baccalaureate) / V Year Pharm-D Degree Examination – 21-Jan-2020
Time: Three Hours
--- Content provided by FirstRanker.com ---
Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS AND THERAPEUTIC DRUG MONITORING
Q.P. CODE: 2876 / 2892
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
--- Content provided by FirstRanker.com ---
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
- What are nomograms? Explain their applications in Pharmacokinetic studies with examples. Give their advantages and disadvantages.
- Enumerate the various causes for renal impairment. Discuss in detail the PK considerations in the renal failure patients.
- Explain the necessity and process of TDM in patients receiving lithium.
SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
--- Content provided by FirstRanker.com ---
- Explain the sampling design used in POPPK study.
- Explain the various pharmacokinetic drug interactions with suitable examples.
- Explain the effect of age and body weight in individualization of drug dosage regimens.
- Describe the Wagner method for the dose adjustment in uremic patients.
- Discuss the factors to be considered in designing the dosage regimen.
- Describe the role of genetic polymorphism in drug targets.
- Describe hemodialysis with its advantages and disadvantages.
- Explain with suitable example how elimination half-life of a drug influences the duration of activity.
--- Content provided by FirstRanker.com ---
SHORT ANSWERS 10 x 2 = 20 Marks
- Define loading dose and maintenance dose. Give equations to calculate the same.
- List the markers used in the measurement of GFR.
- Differentiate between inter-individual variation and within subject variation.
- What is clearance? Give the relationship between clearance and AUC.
- Give any two examples for clinically important genetic polymorphism of drug transporters.
- Add a note on BEER's criteria for drugs used in geriatric patients.
- Give the Jellife's equation for the measurement of creatinine clearance.
- Give the assumptions of one compartment modeling
- List various software's used for conducting POPPK analysis.
- Give MDRD equation for the measurement of creatinine clearance.
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
--- Content provided by FirstRanker.com ---
This download link is referred from the post: RGUHS MPT Last 10 Years 2011-2021 Previous Question Papers || Rajiv Gandhi University of Health Sciences
--- Content provided by FirstRanker.com ---