Download RGUHS Pharma D 2020 5th Year 2876 2892 Clinical Pharmacokinetics And Therapeutic Drug Monitoring Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharma-D (Doctor of Pharmacy) 2020 5th Year 2876 2892 Clinical Pharmacokinetics And Therapeutic Drug Monitoring Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
V Year Pharm-D (II Year Pharm D Post Baccalaureate) / V Year Pharm-D Degree
Examination ? 21-Jan-2020
Time: Three Hours





Max. Marks: 70 Marks
CLINICAL PHARMACOKINETICS AND THERAPEUTIC DRUG MONITORING
Q.P. CODE: 2876 / 2892
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (Answer any two)
2 x 10 = 20 Marks
1. What are nomograms? Explain their applications in Pharmacokinetic studies with examples. Give
their advantages and disadvantages.
2. Enumerate the various causes for renal impairment. Discuss in detail the PK considerations in the
renal failure patients.
3. Explain the necessity and process of TDM in patients receiving lithium.
SHORT ESSAYS (Answer any six)
6 x 5 = 30 Marks
4. Explain the sampling design used in POPPK study.
5. Explain the various pharmacokinetic drug interactions with suitable examples.
6. Explain the effect of age and body weight in individualization of drug dosage regimens.
7. Describe the Wagner method for the dose adjustment in uremic patients.
8. Discuss the factors to be considered in designing the dosage regimen.
9. Describe the role of genetic polymorphism in drug targets.
10. Describe hemodialysis with its advantages and disadvantages.
11. Explain with suitable example how elimination half-life of a drug influences the duration of activity.
SHORT ANSWERS
10 x 2 = 20 Marks
12. Define loading dose and maintenance dose. Give equations to calculate the same.
13. List the markers used in the measurement of GFR.
14. Differentiate between inter-individual variation and within subject variation.
15. What is clearance? Give the relationship between clearance and AUC.
16. Give any two examples for clinically important genetic polymorphism of drug transporters.
17. Add a note on BEER's criteria for drugs used in geriatric patients.
18. Give the Jellife's equation for the measurement of creatinine clearance.
19. Give the assumptions of one compartment modeling
20. List various software's used for conducting POPPK analysis.
21. Give MDRD equation for the measurement of creatinine clearance.
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