RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination
Time: Three Hours Max. Marks: 100 Marks
BIO-PHARMACEUTICS AND PHARMACOKINETICS
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(Revised Scheme 4)
Q.P. CODE: 9338
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary. Answer any ten questions.
LONG ESSAY (Answer any TEN) 10 X 10 = 100 Marks
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- Discuss in detail the drug related factors affecting absorption of drugs.
- Define Bioavailability and Bioequivalence. Explain the methods to estimate bioavailability.
- Describe In-Vitro methods for the evaluation of drug absorption.
- Explain the theories proposed for the dissolution process with labeled diagram.
- Classify compartment models. Explain them with concept and schematic representation.
- Explain one compartment model with respect to extra vascular administration.
- Describe Mixed order kinetics.
- Define protein binding. Explain its kinetics and significance in detail.
- Define AUC. Explain the various methods of determining AUC.
- Explain the terms biotransformation and detoxification. What are the applications of biotransformation? Describe the metabolism of drugs by conjugation reactions.
- Explain the mechanism involved in the renal excretion of drugs with suitable examples.
- Define multiple dosage regimen. Write the advantages and disadvantages of Multiple dosage regimen. Explain the concept of loading dose in multiple oral dosing.
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