RGUHS MHA Last 10 Years 2011-2021 Question Papers (1st Sem, 2nd Sem, 3rd Sem And 4th Sem)
SECTION A (Answer any Three) 3 X 10 = 30 Marks
Firstranker's choice . .
- Explain different experimental approaches for determination of physicochemical parameters.
- Discuss about the agents acting on DHFR and HIV protease enzymes.
- How do you predict ADMET properties of small molecules and what is their importance in drug design?
- What is pharmacophore? Explain the concept, mapping and modeling of pharmacophore.
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SECTION B (Answer any Nine) 9 X 5 = 45 Marks
- Enlist various methods used for calculation of partition co-efficient. Explain any one method.
- Explain historical development of QSAR.
- Discuss the relationship between Hansch and Free Wilson analysis.
- What are the primary requirements to carry out a 3D QSAR study?
- Explain the role of contour map analysis in 3D QSAR.
- Discuss the role of quantum mechanics in drug design.
- Discuss in brief about fragment-based drug design.
- Define molecular docking and discuss the different methods of molecular docking.
- Discuss in detail about Virtual screening techniques.
- Explain briefly about modeling and generation of 3D structure of proteins.
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