Download RGUHS M.Pharm 2nd Year 2020 5159 Computer Aided Drug Design Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharm (Master of Pharmacy) 2nd Year (2nd Semester) 2020 5159 Computer Aided Drug Design Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
Second Semester M. Pharm Degree Examination - 16-Jan-2020
Time: Three Hours
Max. Marks: 75 Marks
COMPUTER AIDED DRUG DESIGN
Q.P. CODE: 5159
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any Three)
3 X 10 = 30 Marks
1.
Explain different experimental and theoretical approaches for the determination of
physicochemical parameters.
2.
Discuss about the agents acting on DHFR and HIV protease enzymes.
3.
How do you predict ADMET properties of small molecules and what is their importance in drug
design?
4.
What is pharmacophore? Explain the concept, mapping and modeling of pharmacophore.
SHORT ESSAY (Answer any Nine)
9 X 5 = 45 Marks
5.
Enlist various methods used for calculation of partition co-efficient. Explain any one method.
6.
Explain historical development of QSAR.
7.
Discuss the relationship between Hansch and Free Wilson analysis.
8.
What are the primary requirements to carry out a 3D QSAR study?
9.
Explain the role of contour map analysis in 3D QSAR.
10. Discuss the role of quantum mechanics in drug design.
11. Discuss in brief about fragment-based drug design.
12. Define molecular docking and discuss the different methods of molecular docking.
13. Discuss in detail about Virtual screening techniques.
14. Explain briefly about modeling and generation of 3D structure of proteins.
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