q

Firstranker's choice FirstRanker.com

Topic:- BIOSCI PHD S2

1. On selfing an insect of Aa Bb genotype, what proportion of progeny will be recessive homozygous for atleast one gene?

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   [Question ID = 517]

   1. 1/16 [Option ID = 2062]
   2. 3/16 [Option ID = 2063]
   3. 7/16 [Option ID = 2064]
   4. 9/16 [Option ID = 2065]

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   Correct Answer :-

   • 7/16 [Option ID = 2064]

2. A nonsense mutant A reverted to wild type. When this revertant was crossed with a wild type, few mutants with phenotype of A were detected again. This shows that the revertant was

   [Question ID = 518]

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   1. A true revertant [Option ID = 2066]
   2. A suppressor mutation [Option ID = 2067]
   3. A dominant mutation [Option ID = 2068]
   4. A regulator mutation [Option ID = 2069]

   Correct Answer :-

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   • A suppressor mutation [Option ID = 2067]

3. In terms of lac operon regulation, what happens when E. coli is grown in medium containing both glucose and lactose?

   [Question ID = 519]

   1. Both CAP and the lac repressor are bound to the DNA [Option ID = 2070]

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   2. CAP is bound to the DNA but the lac repressor is not [Option ID = 2071]
   3. Lac repressor is bound to the DNA but CAP is not [Option ID = 2072]
   4. Neither CAP nor the lac repressor are bound to the DNA [Option ID = 2073]

   Correct Answer :-

   • Neither CAP nor the lac repressor are bound to the DNA [Option ID = 2073]

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4. Intrinsic pathway of apoptosis is regulated by Bax and Bcl2 wherein:

   [Question ID = 520]

   1. Bax stimulates apoptosis while Bcl2 inhibits apoptosis [Option ID = 2074]
   2. Bax inhibits apoptosis while Bcl2 stimulates apoptosis [Option ID = 2075]

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   3. Both stimulate apoptosis [Option ID = 2076]
   4. Both inhibit apoptosis [Option ID = 2077]

   Correct Answer :-

   • Bax stimulates apoptosis while Bcl2 inhibits apoptosis [Option ID = 2074]

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5. Parkinson's disease is primarily due to degeneration of the:

   [Question ID = 521]

   1. Corticospinal tract [Option ID = 2078]
   2. Cerebellum [Option ID = 2079]
   3. Globus pallidus [Option ID = 2080]

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   4. Substantia nigra [Option ID = 2081]

   Correct Answer :-

   • Substantia nigra [Option ID = 2081]

6. Which one of the following is the most appropriate statement regarding folded proteins?

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   [Question ID = 522]

   1. Tyrosine residues are always buried [Option ID = 2082]
   2. Charged amino acid side chains are always buried [Option ID = 2083]
   3. Non polar amino acid side chains are seldom buried
   4. Charged amino acid side chains are seldom buried [Option ID = 2085]

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7. Which of the following is NOT true about capsules?

   [Question ID = 523]

   1. They consist of secreted material lying outside of the bacterial cell wall [Option ID = 2086]
   2. They can prevent desiccation of bacteria cells [Option ID = 2087]

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   3. They are required for bacteria to grow normally in culture [Option ID = 2088]
   4. They help bacteria resist phagocytosis by macrophages [Option ID = 2089]

   Correct Answer :-

   • They are required for bacteria to grow normally in culture [Option ID = 2088]

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8. A patient suffering from pneumonia and tuberculosis was found to have very low CD4+T cells. In all probability the PRIMARY causative infectious agent belongs to

   [Question ID = 524]

   1. Klebsiella family [Option ID = 2090]
   2. Mycobacterium family [Option ID = 2091]
   3. Retrovirus family [Option ID = 2092]

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   4. Streptococcus family [Option ID = 2093]

   Correct Answer :-

   • Retrovirus family [Option ID = 2092]

9. A living microbe with reduced virulence that is used for vaccination is considered

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   [Question ID = 525]

   1. A toxoid [Option ID = 2094]
   2. Dormant [Option ID = 2095]
   3. Attenuated [Option ID = 2096]
   4. Denatured [Option ID = 2097]

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   Correct Answer :-

   • Attenuated [Option ID = 2096]

10. Which of the following can be described as 'a sequence that can be approximately thousand base pairs upstream or downstream of a eukaryotic promoter and increases gene expression as much as 200-fold.'?

    [Question ID = 526]

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    1. CAAT box [Option ID = 2098]
    2. Enhancer [Option ID = 2099]
    3. Insulator [Option ID = 2100]
    4. TATA box [Option ID = 2101]

    Correct Answer :-

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    • Enhancer [Option ID = 2099]

11. Which interactions promote T cell anergy

    [Question ID = 527]

    1. CD28: CD44 [Option ID = 2102]

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    2. CD28: CD86 [Option ID = 2103]
    3. PD-1: PD-L1 [Option ID = 2104]
    4. CD40:CD62L [Option ID = 2105]

    Correct Answer :-

    • PD-1: PD-L1 [Option ID = 2104]

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12. Some peptides and proteins have been used as drugs. Which of the following statements is not true?

    [Question ID = 528]

    1. Protein drugs suffer a disadvantage in that they could produce an immune response. [Option ID = 2106]
    2. Peptides and proteins generally show poor bioavailability [Option ID = 2107]

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    3. Peptide drugs are susceptible to peptidase enzymes [Option ID = 2108]
    4. Peptide drugs are susceptible to nucleases [Option ID = 2109]

    Correct Answer :-

    • Peptide drugs are susceptible to nucleases [Option ID = 2109]

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13. During each cycle of chain elongation in translation, how many conformational changes does the ribosome undergo that accompany GTP hydrolysis?

    [Question ID = 529]

    1. Zero [Option ID = 2110]
    2. One [Option ID = 2111]
    3. Two [Option ID = 2112]

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    4. Three [Option ID = 2113]

    Correct Answer :-

    • Two [Option ID = 2112]

14. The mammalian oocyte prior to sperm entry is arrested at what stage of cell division?

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    [Question ID = 530]

    1. Prophase of mitosis [Option ID = 2114]
    2. Prophase of meiosis [Option ID = 2115]
    3. G1 phase of mitotic cell cycle [Option ID = 2116]
    4. Metaphase of meiosis II [Option ID = 2117]

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    Correct Answer :-

    • Metaphase of meiosis II [Option ID = 2117]

15. Patient centered case management approach for the treatment of tuberculosis is:

    [Question ID = 531]

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    1. BLOT [Option ID = 2118]
    2. DOTS [Option ID = 2119]
    3. ROT [Option ID = 2120]
    4. SOT [Option ID = 2121]

    Correct Answer :-

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    • DOTS [Option ID = 2119]

16. Which of the following events occur during the stationary phase of bacterial growth?

    P. Rise in cell number stops

    Q. Spore formation in some Gram-positive bacteria such as Bacillus subtilis

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    R. Cell size increases in some Gram-negative bacteria such as Escherichia coli

    S. Growth rate of bacterial cells nearly equals their death rate

    T. Decrease in peptidoglycan crosslinking

    [Question ID = 532]

    1. P, Q and S only [Option ID = 2122]

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    2. P, S and T only [Option ID = 2123]
    3. Q, R and S only [Option ID = 2124]
    4. P, R and T only [Option ID = 2125]

    Correct Answer :-

    • P, Q and S only [Option ID = 2122]

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17. The main function of muscle spindles is to:

    [Question ID = 533]

    1. Provide the specialised membrane that holds nicotinic receptors [Option ID = 2126]
    2. Act as stretch receptors [Option ID = 2127]

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    3. Cause contraction of the muscle [Option ID = 2128]
    4. Act as structural support for the muscles [Option ID = 2129]

    Correct Answer :-

    • Act as stretch receptors [Option ID = 2127]

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18. This antihypertensive drug is contraindicated in patients with bilateral renal artery stenosis:

    [Question ID = 534]

    1. Clonidine [Option ID = 2130]
    2. Terazosin [Option ID = 2131]
    3. Nifedipine [Option ID = 2132]

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    4. Captopril [Option ID = 2133]

    Correct Answer :-

19. Example(s) of major plasma proteins important for drug binding:

    [Question ID = 535]

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    1. Lipoproteins [Option ID = 2134]
    2. Alpha1-acidic glycoproteins [Option ID = 2135]
    3. Albumin [Option ID = 2136]
    4. All of these [Option ID = 2137]

    Correct Answer :-

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    • All of these [Option ID = 2137]

20. Example(s) of an effectively irreversible alpha-adrenergic receptor blocker.

    [Question ID = 536]

    1. Phentolamine [Option ID = 2138]

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    2. Phenoxybenzamine [Option ID = 2139]
    3. Both [Option ID = 2140]
    4. Neither [Option ID = 2141]

    Correct Answer :-

    • Phenoxybenzamine [Option ID = 2139]

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21. Inclusion of a vasoconstrictor in the local anesthetic solution is least likely to prolong the action of:

    [Question ID = 537]

    1. Procaine [Option ID = 2142]
    2. Mepivacaine [Option ID = 2143]

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    3. Lidocaine [Option ID = 2144]
    4. Bupivacaine [Option ID = 2145]

    Correct Answer :-

    • Bupivacaine [Option ID = 2145]

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22. Cholestasis causes

    [Question ID = 538]

    1. Jaundice [Option ID = 2146]
    2. Decrease in serum bilirubin [Option ID = 2147]
    3. Activation of cytochrome P-450 [Option ID = 2148]

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    4. Increased synthesis of clotting factors [Option ID = 2149]

    Correct Answer :-

    • Jaundice [Option ID = 2146]

23. Which of the following antibodies are present in mammalian cells

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    [Question ID = 539]

    1. IgG, IgM, IgE, IgD [Option ID = 2150]
    2. IgG, IgM, IgE, IgK [Option ID = 2151]
    3. IgG, IgM, IgF, IgK [Option ID = 2152]
    4. IgG, IgD, IgF, IgE [Option ID = 2153]

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    Correct Answer :-

    • IgG, IgM, IgE, IgD [Option ID = 2150]

24. Cytokine profile for Th2 Response includes

    [Question ID = 540]

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    1. IL-4, IL-5 [Option ID = 2154]
    2. IFN-gamma, IL-8 [Option ID = 2155]
    3. IL-1, IFN-gamma [Option ID = 2156]
    4. IL-1, IL-8 [Option ID = 2157]

    Correct Answer :-

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    • IL-4, IL-5 [Option ID = 2154]

25. Forward and Side Scatter in flow cytometry gives:

    [Question ID = 541]

    1. Fluorescence enhanced by forward and side channels [Option ID = 2158]

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    2. Fluorescence quenched by scattering in forward and side channels [Option ID = 2159]
    3. Relative size and granularity of cell [Option ID = 2160]
    4. Relative number and size of cells [Option ID = 2161]

    Correct Answer :-

    • Relative size and granularity of cell [Option ID = 2160]

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26. The central cytokine that mediates allergic response is

    [Question ID = 542]

    1. IL-5 [Option ID = 2162]
    2. IFN-gamma [Option ID = 2163]

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    3. IL-8 [Option ID = 2164]
    4. IL-13 [Option ID = 2165]

    Correct Answer :-

    • IFN-gamma [Option ID = 2163]

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27. Isotype matched antibody is used in flowcytometry to

    [Question ID = 543]

    1. Check for specificity of stain of test antibody [Option ID = 2166]
    2. Check for auto-fluorescence of the cell [Option ID = 2167]
    3. Check for bleed over of multiple fluophores [Option ID = 2168]

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    4. To set height of the histogram [Option ID = 2169]

    Correct Answer :-

    • Check for specificity of stain of test antibody [Option ID = 2166]

28. Which of the following hexoses are not epimers?

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    [Question ID = 544]

    1. Glucose and mannose [Option ID = 2170]
    2. Glucose and Gulose [Option ID = 2171]
    3. Glucose and Allose [Option ID = 2172]
    4. Glucose and galactose [Option ID = 2173]

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    Correct Answer :-

    • Glucose and Allose [Option ID = 2172]

29. Mannich reaction involves the

    [Question ID = 545]

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    1. Reactions between aldimines and a-methylene carbonyls [Option ID = 2174]
    2. Amino alkylation of an a-methylene carbonyls with formaldehyde and ammonia [Option ID = 2175]
    3. Formation of B-amino-carbonyl compound [Option ID = 2176]
    4. All of these [Option ID = 2177]

    Correct Answer :-

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    • All of these [Option ID = 2177]

30. Wang resin is one of the standard peptide synthesis resin used with Fmoc (fluorenylmethoxycarbonyl chloride) chemistry, the structure of the resin is represented as:

    [Question ID = 546]

    1. 2-alkoxybenzyl alcohol functionalized polystyrene [Option ID = 2178]

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    2. 2-alkoxybenzyl alcohol functionalized polyvinyl [Option ID = 2179]
    3. 4-alkoxybenzyl alcohol functionalized polystyrene [Option ID = 2180]
    4. 4-alkoxybenzyl alcohol functionalized polyvinyl [Option ID = 2181]

    Correct Answer :-

    • 4-alkoxybenzyl alcohol functionalized polystyrene [Option ID = 2180]

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31. The absolute configuration of following compounds is

    [Question ID = 547]

    1. 1(S); 2(S) [Option ID = 2182]
    2. 1(S); 2(R) [Option ID = 2183]

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    3. 1(R); 2(S) [Option ID = 2184]
    4. 1(R); 2(R) [Option ID = 2185]

    Correct Answer :-

    • 1(S); 2(S) [Option ID = 2182]

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32. The probable 1H NMR spectrum of 4-chlorotoluene (Cl-C6H4-CH3) will show d value at:

    [Question ID = 548]

    1. s, 1.5 and d, 7.0-7.5 [Option ID = 2186]
    2. t, 1.5 and m, 7.5 [Option ID = 2187]
    3. s, 2.4 and d, 7.0-7.5 [Option ID = 2188]

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    4. t, 2.4 and m, 7.5 [Option ID = 2189]

    Correct Answer :-

    • s, 2.4 and d, 7.0-7.5 [Option ID = 2188]

33. Which of the following is correct representation of Hammett equation?

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    [Question ID = 549]

    1. Log (Ko/K) = 1/rs [Option ID = 2190]
    2. Log (ko/k) = s/r [Option ID = 2191]
    3. Log (k/ko) = r/s [Option ID = 2192]
    4. Log (k/ko) =rs [Option ID = 2193]

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    Correct Answer :-

    • Log (k/ko) =rs [Option ID = 2193]

34. Compound B, the smelly component emitted by pulp mills, showed M+ at m/z 62 and also peaks at 63 and 64 in a 100:2.2:4.4 ratio. Fragment peaks were seen at m/z 15, 32 and 47. The 1H NMR spectrum of compound B consisted of only a single peak. Which of the following represents the correct structure of compound B.

    [Question ID = 550]

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    1. Dimethyl sulfoxide [Option ID = 2194]
    2. Thioethanol [Option ID = 2195]
    3. Dimethyl sulphide [Option ID = 2196]
    4. None of these [Option ID = 2197]

    Correct Answer :-

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    • Dimethyl sulphide [Option ID = 2196]

35. A common target enzyme for non-steroidal anti-inflammatory drugs is

    [Question ID = 551]

    1. COX-2 [Option ID = 2198]

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    2. CCK-2 [Option ID = 2199]
    3. CXC-R [Option ID = 2200]
    4. CDK-2 [Option ID = 2201]

    Correct Answer :-

    • COX-2 [Option ID = 2198]

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36. TseTse fly is the vector of the pathogen

    [Question ID = 552]

    1. Wuchereria [Option ID = 2202]
    2. Trypanosoma [Option ID = 2203]

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    3. Plasmodium [Option ID = 2204]
    4. Leishmania [Option ID = 2205]

    Correct Answer :-

37. Structured-activity Relationships shows that the important binding interactions in morphine are the piperidine ring, aromatic ring and hydroxyl groups. A diagram captures these functional groups and their relative orientations. What is the term for this?

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    [Question ID = 553]

    1. Pharmacodynamics [Option ID = 2206]
    2. Pharmacokinetics [Option ID = 2207]
    3. Bioisostere [Option ID = 2208]
    4. Pharmacophore [Option ID = 2209]

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    Correct Answer :-

    • Pharmacophore [Option ID = 2209]

38. Protein S will fold into its native conformation only when protein Q is present in the solution. However, protein Q can fold into its native conformation without protein S. Protein Q, therefore, may function as a

    [Question ID = 554]

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    1. Ligand [Option ID = 2210]
    2. Molecular chaperone [Option ID = 2211]
    3. Protein precursor [Option ID = 2212]
    4. Structural motif [Option ID = 2213]

    Correct Answer :-

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    • Molecular chaperone [Option ID = 2211]

39. Which of the following molecules is commonly used as a fluorophore?

    [Question ID = 555]

    1. Phenolphthlein [Option ID = 2214]

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    2. Fluorescein [Option ID = 2215]
    3. Bromophenol blue [Option ID = 2216]
    4. All of these [Option ID = 2217]

    Correct Answer :-

    • Fluorescein [Option ID = 2215]

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40. Name of the monomer used to produce Orlon is

    [Question ID = 556]

    1. Vinyl cyanide [Option ID = 2218]
    2. Formaldehyde + Phenol [Option ID = 2219]

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    3. Adipic acid + Hexamethylenediamine [Option ID = 2220]
    4. Dimethyl terephthalate + Ethylene glycol [Option ID = 2221]

    Correct Answer :-

    • Vinyl cyanide [Option ID = 2218]

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41. Which of the following possess a SP-carbon in its structure?

    [Question ID = 557]

    1. CH2=CCI-CH=CH2 [Option ID = 2222]
    2. CH2=CH-CH=CH2 [Option ID = 2223]
    3. CH2=C=CH2 [Option ID = 2224]

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    4. CH3-CH=CH-CH=CCl2 [Option ID = 2225]

    Correct Answer :-

    • CH2=C=CH2 [Option ID = 2224]

42. Citral, a natural compound isolated from lemon grass oil is

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    [Question ID = 558]

    1. A polyphenol plante
    2. A terpinoid [Option ID = 2227]
    3. An unnatural amino acid [Option ID = 2228]
    4. A carotenoid [Option ID = 2229]

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    Correct Answer :-

    • A terpinoid [Option ID = 2227]

43. Arrange the following compounds in order of their decreasing boiling points

    a) CH3CH2CH2CHO,

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    b) CH3CH2CH2CH2OH,

    c) H5C2-O-C2H5,

    d) CH3CH2CH2CH2CH3

    [Question ID = 559]

    1. a > b > c > d [Option ID = 2230]

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    2. c > b > a > d [Option ID = 2231]
    3. a > b > d > c [Option ID = 2232]
    4. b > a > d > c [Option ID = 2233]

    Correct Answer :-

    •b>a> d > c [Option ID = 2233]

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44. CD is the difference between the absorption of left and right handed circularly polarized light as a function of wavelength. In the following (e=extinction, c=concentration, l= pathlength). Which one is incorrect?

    [Question ID = 560]

    1. CD=DA/(absorbance units)=4pq(degrees)/(180 ln10) [Option ID = 2234]
    2. CD= [eL (l) - eR (1)]lc [Option ID = 2235]

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    3. CD = De (l)lc [Option ID = 2236]
    4. CD = ecl [Option ID = 2237]

    Correct Answer :-

    • CD=DA/(absorbance units)=4pq(degrees)/(180 ln10) [Option ID = 2234]

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45. Pernicious anemia is caused by

    [Question ID = 561]

    1. Auto antibodies to intrinsic factor [Option ID = 2238]
    2. Auto antibodies to vitamin B12 [Option ID = 2239]
    3. Auto antibodies to RBC antigens [Option ID = 2240]

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    4. None [Option ID = 2241]

    Correct Answer :-

    • Auto - antibodies to intrinsic factor [Option ID = 2238]

46. Atopic individuals

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    [Question ID = 562]

    1. Show increased sensitivity to allergens [Option ID = 2242]
    2. Are more prone to auto-immune disorders [Option ID = 2243]
    3. Are resistant to bacterial infections [Option ID = 2244]
    4. Resistant to viral infections [Option ID = 2245]

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    Correct Answer :-

    • Show increased sensitivity to allergens [Option ID = 2242]

47. Match the items in GroupI with Group II:

    [Question ID = 563]

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    Group I

    A. Circular Dichroism

    B. X-ray Crystallography

    C. Freeze-drying

    D. Ultracentrifugation

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    Group II

    I. Dehydration

    II. Sedimentation Coefficient

    III. Secondary structure determination

    IV. Tertiary structure determination

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    Choose the correct answer from the options given below:

    1. AIV, BI, C - II, D - III [Option ID = 2246]
    2. AI, BIV, C - III, D - II [Option ID = 2247]
    3. A II, BIII, CIV, D-1 [Option ID = 2248]
    4. A III, BIV, C - I, D - II [Option ID = 2249]

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    Correct Answer :-

    • A III, BIV, C - I, D - II [Option ID = 2249]

48. ______ are inhibitory interneurons which modulate motor functions by sharpening the signals and secrete _____ for exerting their function.

    [Question ID = 564]

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    1. Renshaw cells; glycine [Option ID = 2250]
    2. Red nuclei; L-Dopamine [Option ID = 2251]
    3. Gamma neurons; glycine [Option ID = 2252]
    4. Alpha neurons; Acetylcholine [Option ID = 2253]

    Correct Answer :-

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    • Renshaw cells; glycine [Option ID = 2250]

49. Yeast two hybrid technique is used for the study of:

    [Question ID = 565]

    1. Protein and protein interactions [Option ID = 2254]

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    2. DNA and Protein interactions [Option ID = 2255]
    3. RNA and Protein interactions [Option ID = 2256]
    4. All of these [Option ID = 2257]

    Correct Answer :-

    • Protein and protein interactions [Option ID = 2254]

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50. Homeostatic regulation of feeding is controlled by

    [Question ID = 566]

    1. Hypothalamus and hind brain [Option ID = 2258]
    2. Mid brain and hind brain [Option ID = 2259]

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    3. Higher cortical regions and hind brain [Option ID = 2260]
    4. Limbic system [Option ID = 2261]

    Correct Answer :-

    • Hypothalamus and hind brain [Option ID = 2258]

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