Download AKTU B-Tech 5th Sem 2015-2016 Bio Informatics 1 Nbt 502 Question Paper

Download AKTU (Dr. A.P.J. Abdul Kalam Technical University (AKTU), formerly Uttar Pradesh Technical University (UPTU) B-Tech 5th Semester (Fifth Semester) 2015-2016 Bio Informatics 1 Nbt 502 Question Paper

Printed Pages: 3 688 . NBT502
(Following Paper ID and Roll No. to be ?lled in your
Answer Book)
Roll No.
B.Tech.
(SEM. V) THEORY EXAM. 2015-16
BIO-INFORMATICS?l
[Time:3 hours] . ' [Toial Marks:100]
Secti?n-A
1. Attempt all parts. All parts carry equal marks. Write
answer of each part in short. (2x1 O=20)
(a) De?ne homology.
(b) What is regular expression?
(0) De?ne the protein domain. '
((1) De?ne pairwise alignment.
(6) What is ClustalW?
(0 What is PHI?BLAST??
(g) De?ne phylogeny. I
(h) De?ne alpha helix.
1150 . (1) P.T.O.

(i) What is the template structure?
0) What is the use of Jmol program?
Section-B
Note : Ateempt any five questions. from this section.
1150
(10x5=50)
Perfrom an optimal global alignment for the DNA
sequences GAATTC and GATTA using dynamic
programming (scoring: +2 for a match, -I for a mismatch,
amd 2 for a linear gap penalty).
HOW do PAM?and BlOSUM can be used in database
similarty serach? Explain.
What is the role of multiple sequence alignment? Explain
the Clustal?W program. a
De?ne the tertiary structure of a protein? Discuss the
method of homology modeling.
Explain the Chou?Fasman method for analysis of protein
secondary structrue elements.
De?ne RMSD. Discuss the uses of RASMOL program.
Explain the rational dru g design approach.
, What are the various ?le formats?
0
(2) NBT?502
Section-C
Note : Attempt any two questions from this section.
10.
11.
12.
1150
(2x15=30)
Explain the concept of dendogram. Descuss the UPGMA
method for phylogenetic tree construction.
Write short notes on:
i) IEDB
ii) EMBL
What do you mean by protein structure visualization?
Describe recently developed tools available for
visualization and analysis of protein structures.
_x__
(3) NBT-502