Download DNB 2015 Dec BIOCHEMISTRY III Question Paper

Download DNB (Diplomate of National Board) Under NBE 2015 Dec BIOCHEMISTRY III Previous Question Paper

FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2015
POSSESSION / USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
BIOCHEMISTRY

PAPER ? III
BIO/D/15/03/III
Time : 3 hours
Max. Marks : 100

Important instructions:

? Attempt all questions in order.
? Each question carries 10 marks.
? Read the question carefully and answer to the point neatly and legibly.
? Do not leave any blank pages between two answers.
? Indicate the question number correctly for the answer in the margin space.
? Answer all the parts of a single question together.
? Start the answer to a question on a fresh page or leave adequate space between two answers.
? Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. Write various post-translational modifications of a newly synthesized
peptide. Giving a suitable example, explain how post translational
modification is important for maturation and functionality of a protein.

5+5
2. What do you understand by cDNA microarray? Write its principle and
clinical applications.

3+(3+4)
3. Describe the structure of an immunoglobulin. List the different types
of immunoglobulin alongwith their functions.

5+5
4. Explain the term restriction fragment length polymorphism (RFLP).
Describe the procedure with examples. List applications of RFLP.

3+4+3
5. Write the molecular mechanisms by which p53

and retinoblastoma
regulate the cell cycle progression. Name different DNA repair
mechanisms that exist in human cells.

6+4
6. What is meant by denaturation of DNA? Define hyperchronicity of
denaturation. Write briefly about melting temperature of DNA.

5+5
7. What is non-specific immunity? Write in detail about its various
components.

4+6
8. What are complements? Write in detail about its role in immunity?

3+7
9. a) Hypersensitivity
b) SCID(Severe Combined Immunodeficiency Disease)
c) Ribozymes
d) SNP (Single nucleotide polymorphism)

2.5x4=10

10. a) Compare and contrast stem cells and cancer cells.
b) Giving a suitable example, explain the role of oncogenes and
tumor suppressor genes in transformation of normal cells to
cancerous cells.
4+6
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