Download DNB 2015 Dec BIOCHEMISTRY III Question Paper

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FINAL EXAM

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NATIONAL BOARD OF EXAMINATIONS

BIO/D/15/03/111

DECEMBER 2015

BIOCHEMISTRY

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PAPER - lll

Time : 3 hours

Max. Marks : 100

Important instructions:

• Attempt all questions in order.

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• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.

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• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. Write various post-translational modifications of a newly synthesized peptide. Giving a suitable example, explain how post translational modification is important for maturation and functionality of a protein. 5+5
2. What do you understand by cDNA microarray? Write its principle and clinical applications. 3+(3+4)

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3. Describe the structure of an immunoglobulin. List the different types of immunoglobulin along with their functions. 5+5
4. Explain the term restriction fragment length polymorphism (RFLP). Describe the procedure with examples. List applications of RFLP. 3+4+3
5. Write the molecular mechanisms’ by which p53 and retinoblastoma regulate the cell cycle progression. Name different DNA repair mechanisms that exist in human cells. 6+4
6. What is meant by denaturation of DNA? Define hyperchronicity of denaturation. Write briefly about melting temperature of DNA. 5+5
7. What is non-specific immunity? Write in detail about its various components. 4+6

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8. What are complements? Write in detail about its role in immunity? 3+7
9. Write short notes on:
   1. Hypersensitivity
   2. SCID(Severe Combined Immunodeficiency Disease)
   3. Ribozymes
   4. SNP (Single nucleotide polymorphism)

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   2.5x4=10
10. 1. Compare and contrast stem cells and cancer cells. 4
    2. Giving a suitable example, explain the role of oncogenes and tumor suppressor genes in transformation of normal cells to cancerous cells. 6

POSSESSION / USE OF CELL PHONES IS NOT PERMITTED INSIDE THE EXAMINATION HALL.

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