Download DNB 2015 Dec BIOCHEMISTRY IV Question Paper

Download DNB (Diplomate of National Board) Under NBE 2015 Dec BIOCHEMISTRY IV Previous Question Paper

FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2015
POSSESSION / USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
BIOCHEMISTRY

PAPER ? IV
BIO/D/15/03/IV
Time : 3 hours
Max. Marks : 100

Important instructions:

? Attempt all questions in order.
? Each question carries 10 marks.
? Read the question carefully and answer to the point neatly and legibly.
? Do not leave any blank pages between two answers.
? Indicate the question number correctly for the answer in the margin space.
? Answer all the parts of a single question together.
? Start the answer to a question on a fresh page or leave adequate space between two answers.
? Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. What in DNA electrophoresis? Give its principle and uses in a clinical
laboratory.

2+8
2. Write the principle of cell sorting by flow cytometry. Name cell surface
markers used for sorting of cancer-stem cells from non-stem cancer
cells.

5+5
3. What is chromatography? Give principles of adsorption and partition
chromatography.

2+(4+4)
4. What are the markers of bone turnover? Add a note a their clinical
significance.

5+5
5. a) What are life style diseases?
b) How can they be managed?
c) Write the molecular mechanisms by which obesity predisposes a
person to coronary heart disease.

2+4+4


6. What are stem cells? Add a note on their therapeutic potential and its
controversies.

2+(4+4)
7. Write the properties and biological effects of dietary fibres in health
and disease. Write the mechanism of digestion and absorption of
dietary lipids in intestine.

5+5
8. State the principle of RT (Reverse Transcriptase)-PCR. Write its
application in research and diagnosis giving suitable examples.

4+6
9. a) What is the biochemical basis for the action of oral contraceptives?
b) State the advantages and disadvantages of DNA vaccination.

5+5


10. Justify that heart is an endocrine organ and its clinical significance.

5+5
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