Download DNB 2015 Dec PHARMA P II Question Paper

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FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2015

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Time : 3 hours
Max. Marks : 100

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Important instructions:

1. Attempt all questions in order.
2. Each question carries 10 marks.
3. Read the question carefully and answer to the point neatly and legibly.
4. Do not leave any blank pages between two answers.

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5. Indicate the question number correctly for the answer in the margin space.
6. Answer all the parts of a single question together.
7. Start the answer to a question on a fresh page or leave adequate space between two answers.
8. Draw table/diagrams/flowcharts wherever appropriate.

1. a) Drugs used in eradication of H.pylori infection. 5+(3+2)
   

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   b) Adverse effects and precautions while using bismuth.
2. a) Selective Cox-2 inhibitors. 3+3+4
   b) What are the advantages over non selective Cox inhibitors?
   c) Elaborate evidence of cardiovascular risk associated with Cox-I inhibitor.
3. a) How low dose aspirin is useful in coronary artery disease? 4+(2+2+2)
   

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   b) Mechanism of action, adverse effects and precautions while using aspirin.
4. a) Classify hypolipidemic agents. 2+2+(2+2)+2
   b) Mechanisms of action of statins.
   c) Enumerate adverse effects and precautions during use of statins.
   d) Pleotropic effects of statins.

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5. a) Mechanism of action and therapeutic use of phenytoin. 2+(2+2)+4
   b) Treatment of status epilepticus.
6. a) Classify antiviral drugs. Write the current guidelines regarding (2+3)+(3+2)
   treatment of HIV-infections.
   b) Mechanism of action and adverse effects of efavirenz.

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7. a) Mention immuno suppressive agents. 3+(2+2+3)
   b) Mechanism of action, adverse effect and use of cyclosporine.
8. Principle and uses of:
   a) Spectrophotometer 5+5
   b) LCMS.

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9. a) Molecular adaptations responsible for opiate withdrawal.
   b) Role of various agents used in opiate withdrawal.
10. a) Firstline and second line drugs used in tuberculosis.
    b) Adverse effect, drug interactions and precaution of Rifampicin and its analogs.

POSSESSION / USE OF CELL PHONES IS NOT PERMITTED INSIDE THE EXAMINATION HALL.

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